본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental cell research v.361 no.1, 2017년, pp.39 - 45   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

CXCR5+ CD8+ T cells potently infiltrate pancreatic tumors and present high functionality

Bai, Minghui (The Second Ward, Department of Hepatobiliary and Hernia Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China ) ; Zheng, Youwei (Department of Hepatobiliary and Hernia Surgery, The First Affiliated Hospital of Henan Science and Technology Univeristy, Luoyang, Henan, China ) ; Liu, Haichao (The Second Ward, Department of Hepatobiliary and Hernia Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China ) ; Su, Baowei (The Second Ward, Department of Hepatobiliary and Hernia Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China ) ; Zhan, Yong (The Second Ward, Department of Hepatobiliary and Hernia Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China ) ; He, Hua (The Second Ward, Department of Hepatobiliary and Hernia Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, Henan, China ) ;
  • 초록  

    Abstract Despite continued improvement in conventional therapy, pancreatic cancer continues to be one of the deadliest tumors worldwide with abysmal 5-year survival rate. New immunotherapeutic strategies that aim at improving antitumor cytotoxic CD8 + T cell responses are being developed in solid tumors. To assist the development of immunotherapies, we investigated the CD8 + T cells in pancreatic cancer patients. Compared to healthy individuals, pancreatic cancer patients presented a significant enrichment in the frequency of CD8 + CXCR5 + T cells. In the tumor microenvironment, the frequencies of CD8 + CXCR5 + T cells were further increased. In most cases, over half of tumor-infiltrating CD8 + T cells were CD8 + CXCR5 + T cells. Compared to the circulating population, the tumor-infiltrating CD8 + CXCR5 + T cells expressed higher levels of PD-1 and TIM-3. Functional analyses demonstrated that upon CD3/CD28 activation, the percentages of TNF-expressing and IFN-γ-expressing cells in CD8 + CXCR5 + T cells were significantly higher than that in CD8 + CXCR5 - T cells. CD8 + CXCR5 + T cells also presented enhanced cytotoxicity than CD8 + CXCR5 - T cells. Upon PD-1 and TIM-3 blockade, the functions of CD8 + CXCR5 + T cells were further improved. The disease-free survival of pancreatic cancer patients following tumor resection was positively correlated with the frequencies of circulating and tumor-infiltrating CD8 + CXCR5 + T cells. Together, our study identified that CD8 + CXCR5 + T cells were a potent subset of CD8 + T cells that were highly enriched in pancreatic cancer patients and could respond to anti-PD-1/anti-TIM-3 blockade by further upregulation in function.


  • 주제어

    CD8+CXCR5+ T cells .   Pancreatic cancer.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기