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Experimental cell research v.361 no.1, 2017년, pp.149 - 154   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

CD21lo/medCD27+ proinflammatory B cells are enriched in breast cancer patients and promote antitumor T cell responses

Zhu, Shiguang (Corresponding author. ); Wang, Xingmiao ( ); Wang, Ji ( ); Lin, Jun ( ); Cong, Yizi ( ); Qiao, Guangdong ( );
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    Abstract Breast cancer is a common malignancy and a major cause of death in women worldwide. The immunomodulatory role of B cells is being increasingly recognized in autoimmune diseases and cancers. In recent years, immunotherapeutic strategies that upregulate the patient's own antitumor T cell responses have shown promise in treating solid tumors and are being developed for breast cancer. In this study, we discovered that the B cells in breast cancer patients were enriched with interferon (IFN)-γ-expressing cells and presented high potency for IFN-γ production. These IFN-γ-expressing B cells were enriched in, but did not completely overlap with, the CD21 lo/med CD27 + IgM - IgD - IgG + IgA - B cell subset, which was consistent with IgG-expressing memory B cells. Compared to CD27 + IgG - B cells, the CD27 + IgG + B cells expressed significantly higher IFN-γ expression. Given that B cells demonstrate important antigen-presenting function to T cells, we incubated CD27 + IgG - B cells and CD27 + IgG + B cells with autologous CD4 + T cells. Compared to the CD4 + T cells that were incubated with CD27 + IgG - B cells, the CD4 + T cells that were incubated with CD27 + IgG + B cells presented significantly higher TBX21 and lower FOXP3 expression, suggesting that the CD27 + IgG + B cells, but not the CD27 + IgG - B cells, promoted Th1 and suppressed regulatory T cell responses. IFN-γ-expressing B cells were further enriched in the intratumoral environment of breast cancer patients. Together, we discovered that breast cancer patients presented an upregulation of IFN-γ-expressing proinflammatory B cells with the potency to promote Th1 responses.


  • 주제어

    CD21 .   CD27 .   B cell .   Breast cancer.  

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