본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental cell research v.361 no.1, 2017년, pp.155 - 162   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The histone demethylase JMJD2A regulates the expression of BDNF and mediates neuropathic pain in mice

Zhou, Junfei (Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China ) ; Wang, Fang (Department of Pain Management, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China ) ; Xu, Chang (Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China ) ; Zhou, Zipeng (Department of Rheumatology, Henan Province Hospital of TCM, Zhengzhou, China ) ; Zhang, Wei (Department of Anesthesiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China ) ;
  • 초록  

    Abstract JMJD2A is a JmjC histone demethylase that catalyzes the demethylation of di- and trimethylated Lys9 and Lys36 in histone H3 (H3K9me2/3 and H3K36me2/3). The role of spinal JMJD2A-dependent histone demethylation in nociception hypersensitivity development remains elusive. Here we reported that the JMJD2A responded to neuropathic pain and participated in the maintenance of neuropathic pain. The mRNA and protein levels of Jmjd2a were significantly increased in the neurons of mouse undergoing neuropathic pain induced by sciatic nerve chronic constrictive injury (CCI) or unilateral spared nerve injury (SNI). Jmjd2a responded to 5-hydroxytryptamine (5-HT) and promoted the expression of the brain-derived neurotrophic factor ( Bdnf ), which is a protein critically involved in neuropathic pain. JMJD2A bound to the promoter of Bdnf and demethylated H3K9me3 and H3K36me3 at Bdnf promoter to promote the expression of Bdnf. Finally, we showed that JMJD2A promoted the expression of Bdnf during neuropathic pain and neuron-specific knockout of Jmjd2a blocked the hypersensitivity of mice undergoing chronic neuropathic pain induced by CCI and SNI. Taken together, our findings demonstrate that up-regulation of JMJD2A promotes neuropathic pain and it may serve as a promising target for treatment of chronic neuropathic pain. Highlights JMJD2A is upregulated during chronic neuropathic pain. JMJD2A is regulated by 5-hydroxytryptamine (5-HT). JMJD2A promotes the expression of brain-derived neurotrophic factor (Bdnf) . JMJD2A regulates the levels of H3K9me3 and H3K36me3 at the promoter of Bdnf . JMJD2A regulates Bdnf to participate in chronic neuropathic pain.


  • 주제어

    JMJD2A .   5-hydroxytryptamine .   BDNF .   Neuropathic pain .   Histone demethylase.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기