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Microvascular research v.115, 2018년, pp.1 - 7   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Differences in laser-Doppler indices between skin-surface measurement sites in subjects with diabetes

Hsiu, Hsin (Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan ); Hu, Hsiao-Feng (Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan ); Tsai, Hung-Chi (Graduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan );
  • 초록  

    Abstract This study performed laser-Doppler flowmetry (LDF) measurements with the aim of identifying differences in diabetes-induced microcirculatory-blood-flow (MBF) responses between the following skin surface measurement sites: an acupoint around the wrist, an acupoint around the ankle, and a nearby nonacupoint around the ankle. The 67 study subjects were assigned to diabetic, prediabetic, and healthy groups according to the results of oral glucose tolerance tests. Beat-to-beat and spectral analyses were applied to the LDF waveform to obtain the foot delay time (FDT), the flow rise time (FRT), and the relative energy contributions (RECs) in five frequency bands. FRT and FDT were significantly shorter and the RECs of the endothelial-, neural-, and myogenic-related frequency bands were significantly smaller in the diabetic group than in the control group at the acupoint around the ankle, but there were no such prominent differences at the other sites. The acupoint around the ankle was better than the nearby nonacupoint and the acupoint around the wrist for distinguishing the age-matched diabetic, prediabetic, and healthy subjects. These findings imply that when monitoring diabetes-induced MBF responses, the measurement locations should be chosen carefully in order to minimize interference effects and to improve the ability to distinguish subjects with different conditions. Highlights LDF measurements to identify differences in diabetes-induced MBF responses Between acupoint around the wrist, acupoint and nearby nonacupoint around the ankle Acupoint around the ankle better distinguishes diabetic and healthy subjects. Measurement locations should be chosen carefully to minimize interference effects.


  • 주제어

    Diabetes .   Laser Doppler .   Acupoint .   Beat-to-beat waveform .   Spectral analysis.  

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