논문 상세정보
Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients
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초록
Abstract Objective To identify possible correlations between skin blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients. Methods Sixty-two SSc patients, according to 2013 EULAR/ACR criteria, and 62 healthy subjects (CNT) were enrolled. Skin BP was analysed by laser speckle contrast analysis (LASCA) at the level of dorsum of the middle phalanx of the third fingers, dorsal aspect of the hands and zygoma. DT was assessed by both skin high frequency ultrasound (US) and modified Rodnan skin score (mRSS) in the same above reported areas. All patients were studied also by nailfold videocapillaroscopy (NVC) to assess the proper pattern of microvascular damage (“Early”, “Active”, or “Late”). Results At the level of finger dorsum a statistically significant negative correlation was observed in SSc patients between skin BP and both ultrasound-DT (p=0.0005 r=0.43) and mRSS (p=0.0007 r=0.42), but not at the level of hand dorsum and zygoma. No statistically significant correlation was present between skin BP and ultrasound-DT at any level in CNT. In detail, SSc patients, compared to CNT, showed a statistically significant lower BP only at level of fingers (median PU 72.6 vs 136.1 respectively, p Conclusions This study demonstrates for the first time in SSc patients a significant inverse relationship between skin BP, measured by LASCA, and DT, evaluated by both US and mRSS, at the level of dorsum of the middle phalanx of the third fingers. Highlights Imaging is an important adjunct to quantify and follow some aspects of SSc. Both LASCA and skin high frequency ultrasound are safe and not invasive techniques. Both LASCA and skin high frequency ultrasound allow to follow-up several aspects of the disease course in SSc patients. LASCA and US together may give the possibility to quantify in SSc the therapeutic effects of different regimens.
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주제어
Systemic sclerosis . Laser speckle contrast analysis . Skin high-frequency ultrasound . Nailfold videocapillaroscopy . Peripheral blood perfusion . Dermal thickness . Nailfold microangiopathy.
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Cover 2/ Ed. Board
- Cover 2/ Ed. Board
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