본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Microvascular research v.115, 2018년, pp.28 - 33   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Correlations between blood perfusion and dermal thickness in different skin areas of systemic sclerosis patients

Ruaro, B. (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, IRCCS Policlinico San Martino, Genova, Italy ); Sulli, A. (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, IRCCS Policlinico San Martino, Genova, Italy ); Pizzorni, C. (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, IRCCS Policlinico San Martino, Genova, Italy ); Paolino, S. (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine and Medical Specialities, University of Genova, IRCCS Policlinico San Martino, Genova, Italy ); Smith, V. (Department of Rheumatology, Ghent University Hospital, Department of Internal Medicine, Ghent University, Ghent, Belgium ); Alessandri, E. (Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medici ); Trombetta, A.C. ( ); Alsheyyab, J. ( ); Cutolo, M. ( );
  • 초록  

    Abstract Objective To identify possible correlations between skin blood perfusion (BP) and dermal thickness (DT) in different skin areas of systemic sclerosis (SSc) patients. Methods Sixty-two SSc patients, according to 2013 EULAR/ACR criteria, and 62 healthy subjects (CNT) were enrolled. Skin BP was analysed by laser speckle contrast analysis (LASCA) at the level of dorsum of the middle phalanx of the third fingers, dorsal aspect of the hands and zygoma. DT was assessed by both skin high frequency ultrasound (US) and modified Rodnan skin score (mRSS) in the same above reported areas. All patients were studied also by nailfold videocapillaroscopy (NVC) to assess the proper pattern of microvascular damage (“Early”, “Active”, or “Late”). Results At the level of finger dorsum a statistically significant negative correlation was observed in SSc patients between skin BP and both ultrasound-DT (p=0.0005 r=0.43) and mRSS (p=0.0007 r=0.42), but not at the level of hand dorsum and zygoma. No statistically significant correlation was present between skin BP and ultrasound-DT at any level in CNT. In detail, SSc patients, compared to CNT, showed a statistically significant lower BP only at level of fingers (median PU 72.6 vs 136.1 respectively, p Conclusions This study demonstrates for the first time in SSc patients a significant inverse relationship between skin BP, measured by LASCA, and DT, evaluated by both US and mRSS, at the level of dorsum of the middle phalanx of the third fingers. Highlights Imaging is an important adjunct to quantify and follow some aspects of SSc. Both LASCA and skin high frequency ultrasound are safe and not invasive techniques. Both LASCA and skin high frequency ultrasound allow to follow-up several aspects of the disease course in SSc patients. LASCA and US together may give the possibility to quantify in SSc the therapeutic effects of different regimens.


  • 주제어

    Systemic sclerosis .   Laser speckle contrast analysis .   Skin high-frequency ultrasound .   Nailfold videocapillaroscopy .   Peripheral blood perfusion .   Dermal thickness .   Nailfold microangiopathy.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기