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NeuroImage v.160, 2017년, pp.152 - 167   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Functional connectomics from a “big data” perspective

Xia, Mingrui (National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China ) ; He, Yong (National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China ) ;
  • 초록  

    Abstract In the last decade, explosive growth regarding functional connectome studies has been observed. Accumulating knowledge has significantly contributed to our understanding of the brain's functional network architectures in health and disease. With the development of innovative neuroimaging techniques, the establishment of large brain datasets and the increasing accumulation of published findings, functional connectomic research has begun to move into the era of “big data”, which generates unprecedented opportunities for discovery in brain science and simultaneously encounters various challenging issues, such as data acquisition, management and analyses. Big data on the functional connectome exhibits several critical features: high spatial and/or temporal precision, large sample sizes, long-term recording of brain activity, multidimensional biological variables (e.g., imaging, genetic, demographic, cognitive and clinic) and/or vast quantities of existing findings. We review studies regarding functional connectomics from a big data perspective, with a focus on recent methodological advances in state-of-the-art image acquisition (e.g., multiband imaging), analysis approaches and statistical strategies (e.g., graph theoretical analysis, dynamic network analysis, independent component analysis, multivariate pattern analysis and machine learning), as well as reliability and reproducibility validations. We highlight the novel findings in the application of functional connectomic big data to the exploration of the biological mechanisms of cognitive functions, normal development and aging and of neurological and psychiatric disorders. We advocate the urgent need to expand efforts directed at the methodological challenges and discuss the direction of applications in this field. Highlights Functional connectomic (FC) research has moved into the era of “Big Data”. Review methodology advances on acquisition, analysis and statistics of FC big data. Highlight applications of FC big data in cognition, development, aging and diseases. Suggest challenging issues and important directions of FC big data research.


  • 주제어

    Brain networks .   Connectome .   Dynamics .   Graph theory .   Fingerprint .   Big data.  

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