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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.511 - 517   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Overexpression of DBC1, correlated with poor prognosis, is a potential therapeutic target for hepatocellular carcinoma

Li, Changcan (Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China ) ; Liao, Jianhua (Department of General Surgery, Zhejiang Hospital, Hangzhou 310013, China ) ; Wu, Shaohan (Department of General Surgery, The Second Affiliated Hospital of Jiaxing College, Jiaxing 314000, China ) ; Fan, Junwei (Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China ) ; Peng, Zhihai (Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China ) ; Wang, Zhaowen (Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China ) ;
  • 초록  

    Abstract Deleted in Breast Cancer 1 (DBC1) is a regulatory protein involved in cell metabolism and cancer progression. Nevertheless, the expression and prognostic values of DBC1 in hepatocellular carcinoma (HCC) are still not well understood. The following study investigated the clinical significance and biological function of DBC1 in HCC. Briefly, overexpression of DBC1 at transcriptional and translational levels in human HCC tissues compared to adjacent normal tissues was observed using quantitative real-time polymerase chain reaction (qRT-PCR), western blot (WB) and immunohistochemistry (IHC) approach. Furthermore, upregulated DBC1 was significantly correlated with tumor size (p = 0.005), N stage (p = 0.016), M stage (p = 0.011), tumor differentiation (p in vitro . To conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC. Highlights DBC1 was upregulated in HCC tissues and cell lines. Overexpression of DBC1 was correlated with clinicopathological parameters in HCC. Overexpression of DBC1 predicts poor disease-free survival (DFS) and overall survival (OS) in HCC. Knockdown of DBC1 inhibits HCC cell lines proliferation.


  • 주제어

    DBC1 .   Hepatocellular carcinoma .   Prognosis .   Proliferation.  

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