Overexpression of DBC1, correlated with poor prognosis, is a potential therapeutic target for hepatocellular carcinoma
Abstract Deleted in Breast Cancer 1 (DBC1) is a regulatory protein involved in cell metabolism and cancer progression. Nevertheless, the expression and prognostic values of DBC1 in hepatocellular carcinoma (HCC) are still not well understood. The following study investigated the clinical significance and biological function of DBC1 in HCC. Briefly, overexpression of DBC1 at transcriptional and translational levels in human HCC tissues compared to adjacent normal tissues was observed using quantitative real-time polymerase chain reaction (qRT-PCR), western blot (WB) and immunohistochemistry (IHC) approach. Furthermore, upregulated DBC1 was significantly correlated with tumor size (p = 0.005), N stage (p = 0.016), M stage (p = 0.011), tumor differentiation (p in vitro . To conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC. Highlights DBC1 was upregulated in HCC tissues and cell lines. Overexpression of DBC1 was correlated with clinicopathological parameters in HCC. Overexpression of DBC1 predicts poor disease-free survival (DFS) and overall survival (OS) in HCC. Knockdown of DBC1 inhibits HCC cell lines proliferation.
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