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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.587 - 593   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase

Jung, Dae Young (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea ) ; Kim, Ji-Hyun (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea ) ; Lee, Hoyoung (KM Fundamental Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea ) ; Jung, Myeong Ho (Division of Longevity and Biofunctional Medicine, School of Korean Medicine, Pusan National University, Yangsan 50612, Republic of Korea ) ;
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    Abstract Gomisin N (GN) is a lignan derived from Schisandra chinensis . AMP-activated kinase (AMPK) has gained attention as a therapeutic target for the treatment of metabolic syndrome. Previously, we reported that GN activated the AMPK pathway and ameliorated high-fat diet (HFD)-induced hepatic steatosis. In this study, we investigated the anti-diabetic effects of GN in C2C12 myotubes and HFD obese mice. GN enhanced the phosphorylation of AMPK/acetyl-CoA carboxylase (ACC) and Akt. In addition, GN promoted glucose uptake in C2C12 myotubes, which was accompanied by the translocation of glucose transporter 4 (GLUT4) to the plasma membrane. Treatment with compound C, an AMPK inhibitor, suppressed GN-mediated stimulation of glucose uptake. Furthermore, GN increased the expression of mitochondria biogenesis and fatty acid oxidation genes in C2C12 myotubes. In the in vivo study, administration of GN to HFD mice decreased the levels of fasting blood glucose and insulin, and improved glucose tolerance in HFD obese mice. GN administration rescued the decreased phosphorylation of AMPK and Akt and stimulated the expression of mitochondria biogenesis genes in the skeletal muscle of HFD mice. These findings suggested that GN exerted anti-hyperglycemic effects through AMPK activation. Highlights Gomisin N activated AMPK/Akt signaling in C2C12 myotubes. Gomisin N stimulated glucose uptake in C2C12 myotubes. Gomisin N promoted mitochondria biogenesis and fatty acid oxidation in C2C12 myotubes. Gomisin N reduced hyperglycemia and improved glucose tolerance in HFD obese mice. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    AMP-Activated protein kinase .   Antidiabetes .   Fatty acid oxidation .   Gomisin N .   Glucose transporter 4 .   Mitochondria biogenesis.  

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