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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.615 - 620   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study

Tao, Xin (Center for Reproductive Medicine, The Third Affiliated Hospital, Sun-Yet Sen University, People's Republic of China ); Chen, Lei (Center for Reproductive Medicine, The Third Affiliated Hospital, Sun-Yet Sen University, People's Republic of China ); Cai, Lisi (Center for Reproductive Medicine, The Third Affiliated Hospital, Sun-Yet Sen University, People's Republic of China ); Ge, Shuqi (Department of Infertility and Sexual Medicine, The Third Affiliated Hospital, Sun-Yet Sen University, People's Republic of China ); Deng, Xuanying (Center for Reproductive Medicine, The Third Affiliated Hospital, Sun-Yet Sen University, People's Republic of China );
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    Abstract In order to preliminarily explore the correlation between the AMPKα-SIRT1 pathway and insulin resistance and reproductive function in PCOS mice and find the pathogenesis molecular mechanism and potential therapeutic target of PCOS, we carried out in vitro study of human granulosa KGN cells and in vivo study of PCOS mouse model which was constructed with DHEA, and AICAR and Compound C were applied. We have found that SIRT1 and AMPKα expression in KGN cells gradually decreased as DHEA concentration increased; Mice of the PCOS model were in an obvious status of IR (P Highlights The first research connecting the pathogenesis of IR in PCOS with AMPKα-SIRT1 molecular pathway. Hyperandrogenism decreased the expression of AMPKα and SIRT1 in human ovarian granulosa cells. AMPK agonists AICAR can improve the reproductive and endocrine function of PCOS mice. The AMPKα-SIRT1 pathway could be up-regulated after AICAR treatment in the ovaries PCOS mice. AMPKα-SIRT1 pathway may be a molecular mechanism of IR in PCOS and may serve as a therapeutic target.


  • 주제어

    PCOS .   Mice .   Insulin resistance .   AMPKα-SIRT1 molecular pathway.  

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