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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.648 - 655   SCI SCIE
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Exposure to cigarette smoke disturbs adipokines secretion causing intercellular damage and insulin resistance in high fructose diet-induced metabolic disorder mice

Kim, Sanghwa    (Division of Basic Radiation Bioscience, Korea Institute of Radiological & Medical Science, Seoul 01812, Republic of Korea   ); Lee, Ah Young    (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea   ); Kim, Hyeon-Jeong    (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea   ); Hong, Seong-Ho    (Laboratory of Toxicology, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea   ); Go, Ryeo-Eun    (Laboratory of Biochemistry and Immunology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea   ); Choi, Kyung-Chul    (Laboratory of Biochemistry and Immunology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea   ); Kang, Kyung-Sun    (Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University, Seoul 08826, Republic of Korea   ); Cho, Myung-Haing    (Laboratory of Toxicology, College o  );
  • 초록  

    Abstract A large amount of fructose intake along with smoking is associated with increased incidence of diseases linked to metabolic syndrome. More research is necessary to understand the complex mechanism that ultimately results in metabolic syndrome and the effect, if any, of high fructose dietary intake and smoking on individual health. In this study, we investigated changes in ER-Golgi network and disturbance to secretion of adipokines induced by cigarette smoking (CS) and excess fructose intake and their contribution to the disruption of metabolic homeostasis. We used high fructose-induced metabolic disorder mice model by feeding them with high fructose diet for 8 weeks. For CS exposure experiment, these mice were exposed to CS for 28 days according to OECD guideline 412. Our results clearly showed that the immune system was suppressed and ER stress was induced in mice with exposure to CS and fed with high fructose. Furthermore, their concentrations of adipokines including leptin and adiponectin were aberrant. Such alteration in secretion of adipokines could cause insulin resistance which may lead to the development of type 2 diabetes. Highlights Cigarette smoke and fructose excess intake induce disruption to mechanisms involved in ROS generation and ER stress. Damage of cellular organelles induced by cigarette smoke and high fructose feeding affects inflammatory response and alters secretion of adipokines. Cigarette smoking and fructose excess intake are associated with metabolic syndrome.


  • 주제어

    Cigarette smoke .   High fructose diet .   Organelle damage .   ER stress .   Adipokines .   Insulin resistance.  

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