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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.656 - 662   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Supplementing zinc oxide nanoparticles to cryopreservation medium minimizes the freeze-thaw-induced damage to spermatozoa

Isaac, Ann V. (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Kumari, Sandhya (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Nair, Ramya (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Urs, Deepak Raj (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Salian, Sujith Raj (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Kalthur, Guruprasad (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Adiga, Satish Kumar (Department of Clinical Embryology, Central Research Lab, Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India ) ; Manikkath, Jyothsna (Department of Pharmaceutics ) ; Mutalik, Srinivas ; Sachdev, Divya ; Pasricha, Renu ;
  • 초록  

    Abstract The sperm DNA integrity post cryopreservation of human semen samples is one of the serious concerns in human infertility treatment. In the present study, the beneficial effects of zinc oxide nanoparticles in preserving the functional ability of spermatozoa was explored. Ejaculates of normozoospermic men cryopreserved along with Zinc oxide nanoparticles (ZnONPs) exhibited non-significantly higher percentage of total and progressive motility in frozen-thawed samples compared to control. The sperm chromatin damage and malondialdehyde (MDA) level was significantly lower in ZnONPs group ( P P


  • 주제어

    DNA integrity .   Lipid peroxidation .   Semen cryopreservation .   Transmission electron microscopy .   Zinc oxide nanoparticles.  

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