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Biochemical and biophysical research communications v.494 no.3/4, 2017년, pp.674 - 680   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Downregulation of ZMYND11 induced by miR-196a-5p promotes the progression and growth of GBM

Yang, Ji-peng (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Yang, Jian-kai (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Li, Chen (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Cui, Zhi-qiang (Graduate College of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Liu, Hong-jiang (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Sun, Xiao-feng (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Geng, Shao-mei (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Lu, Sheng-kui (Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China ) ; Song, Jian (Department of Neurosurgery, The Second Hospital of Hebe ) ; Guo, Cheng-yong ; Jiao, Bao-hua ;
  • 초록  

    Abstract ZMYND11 (zinc finger MYND-type containing 11) has been widely regarded to be involved in a variety of cancers as a potential suppressor. However, the biological role and mechanism of ZMYND11 in glioblastoma multiform (GBM) remain unknown. In this study, we found that ZMYND11 expression was remarkably decreased in GBM tissues from 20 cases and cell line (U87) compared to normal brain tissue from 10 cases ( P Highlights The expression level of ZMYND11 in GBM tumor tissue and U87 cell line. The role of ZMYND11 upregulation in U87 cells in vitro and vivo. The link of expression level between ZMYND11 and miR-196a-5p in GBM tumor and U87 cells.


  • 주제어

    ZMYND11 .   miRNA-196a-5p .   Glioblastoma multiforme .   Cell proliferation.  

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