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Ecotoxicology and environmental safety v.147, 2018년, pp.423 - 429   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Bisphenol A regulates rare minnow testicular vitellogenin expression via reducing its promoter Er recruitment

Zhang, Yingying (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China ) ; Guan, Yongjing (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China ) ; Fan, Xiaoteng (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China ) ; Wu, Lang (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China ) ; Wang, Zaizhao (College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Yangling, Shaanxi 712100, China ) ;
  • 초록  

    Abstract Vitellogenins (Vtgs) are major precursor of the egg-yolk proteins. They are synthesized in liver of adult female ovipara, but normally silent in males. For their sensitive response to estrogen, Vtgs are usually used as biomarkers for environmental estrogenic compounds. In the present study, three vtg subtypes ( vtg1, vtg2 and vtg3 ) were proved to present in the testis of rare minnow Gobiocypris rarus for the first time. Immunohistochemistry result showed that Vtg proteins mainly deposit in spermatogonium and spermatocytes. Following 225μg/L bisphenol A (BPA) exposure 1, 3 and 9 weeks, testicular vtg mRNAs were mostly significantly decreased. The further chromatin immunoprecipitation showed that BPA could decrease estrogen receptor (Er) recruitment in vtg promoter, which possibly reduced Er's transcription activation effect on vtgs . However, different from the continuously decreased vtg mRNA levels, testicular Vtg protein levels were recovered at week 9. Considering the induced hepatic Vtg expression, testicular Vtgs may be replenished by the induced hepatic Vtgs under BPA exposure. Highlights Three vtg subtypes expressed in the testis of rare minnow. Vtg proteins mainly deposit in spermatogonia and spermatocytes. BPA decreased Er recruitment in vtg promoter. BPA inhibit testicular vtg mRNA and Vtg protein expression. Decreased testicular Vtg could be replenished by induced hepatic Vtgs.


  • 주제어

    Vitellogenin .   Testis .   Rare minnow .   Bisphenol A .   Estrogen receptors.  

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