Synthesis and characterization of triazole based supramolecule for interaction with cefuroxime in tap water and blood plasma
Abstract In this study a new calixarene triazole 5 was successfully synthesized using click reaction and characterized through UV–visible, FT-IR, 1 H NMR spectroscopes and Mass Spectrometry. The supramolecular interaction of compound 5 towards commonly used drugs has been carried out using UV–Visible spectroscopy. The supramolecule 5 showed characteristic enhancement in the absorbance intensity after mixing with Cefuroxime at pH (2–12). Compound 5 displayed considerably good interactions with cefuroxime in the presence of other drugs. Compound 5 exhibits linear relationship with cefuroxime concentration in the range of (10–80μM) with regression value of 0.9954. The standard deviation for 50μM Cefuroxime was found to be 0.01 and the limit of detection for cefuroxime was calculated to be 2μM. Job’s plot experiments showed 1:1 ( 5: cefuroxime) binding stoichiometry between compound 5 and cefuroxime. Supramolecule 5 displayed fairly good spectrophotometric recognition of Cefuroxime in human blood plasma and tap water thus showing that the ingredients of tap water and plasma sample was inert in the recognition of cefuroxime. Highlights New triazole based supramolecus 5 was synthesized and characterized. The probe exhibited the excellent selectivity and sensitivity for cefuroxime in DMSO/H 2 O. The binding stoichiometry between compound 5 and cefuroxime was determined by Job's plot method. The interaction of 5 and cefuroxime was inert to the ingredients of tap water and plasma samples.
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