본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Ecotoxicology and environmental safety v.147, 2018년, pp.720 - 724   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The environmental neurotoxin β-N-methylamino-L-alanine (L-BMAA) is deposited into birds' eggs

Andersson, Marie (Department of Environmental Toxicology, Uppsala University, SE-752 36 Uppsala, Sweden ) ; Karlsson, Oskar (Department of Pharmaceutical Biosciences, Uppsala University, SE-751 24 Uppsala, Sweden ) ; Brandt, Ingvar (Department of Environmental Toxicology, Uppsala University, SE-752 36 Uppsala, Sweden ) ;
  • 초록  

    Abstract The neurotoxic amino acid β-N-methylamino- L -alanine (BMAA) has been implicated in the etiology of neurodegenerative disorders. BMAA is also a known developmental neurotoxin and research indicates that the sources of human and wildlife exposure may be more diverse than previously anticipated. The aim of the present study was therefore to examine whether BMAA can be transferred into birds’ eggs. Egg laying quail were dosed with 14 C-labeled BMAA. The distribution of radioactivity in the birds and their laid eggs was then examined at different time points by autoradiography and phosphoimaging analysis. To evaluate the metabolic stability of the BMAA molecule, the distribution of 14 C-methyl- and 14 C-carboxyl-labeled BMAA were compared. The results revealed a pronounced incorporation of radioactivity in the eggs, predominantly in the yolk but also in the albumen. Imaging analysis showed that the concentrations of radioactivity in the liver decreased about seven times between the 24h and the 72h time points, while the concentrations in egg yolk remained largely unchanged. At 72h the egg yolk contained about five times the concentration of radioactivity in the liver. Both BMAA preparations gave rise to similar distribution pattern in the bird tissues and in the eggs, indicating metabolic stability of the labeled groups. The demonstrated deposition into eggs warrants studies of BMAAs effects on bird development. Moreover, birds’ eggs may be a source of human BMAA exposure, provided that the laying birds are exposed to BMAA via their diet. Highlights The neurotoxin β-N-methylamino- L -alanine (BMAA) bioaccumulates in food chains. We demonstrate that BMAA is secreted in the eggs of laying quail. BMAA could be a developmental neurotoxin in birds, as has previously been shown in rats. Birds’ eggs may be a source of human BMAA exposure.


  • 주제어

    Cyanobacterial neurotoxin .   Birds' eggs .   Secretion .   Developmental toxicity .   Human exposure.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기