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Neurobiology of learning and memory v.146, 2017년, pp.37 - 46   SCI SCIE SSCI
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life

Sinclair, Lindsey I. (School of Social and Community Medicine, University of Bristol, Oakfield House, Bristol BS8 2BN, UK ) ; Pleydell-Pearce, Christopher W. (School of Experimental Psychology, University of Bristol, The Priory Road Complex, Priory Road, Bristol BS8 1TU, UK ) ; Day, Ian N.M. (School of Social and Community Medicine, University of Bristol, Oakfield House, Bristol BS8 2BN, UK ) ;
  • 초록  

    Abstract Background ε4 allele possession is associated with an increased risk of Alzheimer’s disease. Its effects earlier in life are less well understood. Previous studies have reported both detrimental effects and a lack of effect on cognition outside dementia. We used genotype based recall from the ALSPAC study to investigate whether APOE genotype influences cognition in earlier adult life. Methods We invited all individuals with the rarer ε22 or ε44 genotypes and equal numbers of those with ε32, ε33 or ε34 APOE genotypes (total n invited = 1936, ages 23–67). Participants were screened for dementia using the Addenbrooke’s Cognitive Examination Revised (ACE-R). Participants were asked to complete a 3 h battery of neuropsychological tests covering a range of cognitive domains. The primary outcome was performance on the Rey Auditory Verbal Learning Test (RAVLT). Transformation of variables was used where required to permit parametric testing. As genotypes are unlikely to be confounded unadjusted analyses were performed. Results 114 participants were recruited to the study (39 ε33, 27 ε34, 15 ε44, 26 ε32 & 7 ε22). ε4+ participants had higher scores on the cognitive failures questionnaire (10 point increase, p = 0.006) but no deficits on objective cognitive testing. ε2 carriers had slightly better episodic memory performance (p = 0.016), slightly improved n-back accuracy and better executive functioning (trails A&B, p = 0.005). Conclusions It is intriguing that the ε2+ group performed better as this group have a lower risk of Alzheimer’s disease. Most previous studies have analysed as ε4/non ε4 so may have missed this effect. Highlights E4 carriers self reported more memory problems, but no objective differences found. E2 carriers performed slightly better on episodic memory test. E2 carriers were faster in a test of executive function.


  • 주제어

    Apolipoprotein E .   Memory episodic .   Executive functioning .   ALSPAC .   Genetics .   Cognition.  

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