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Gynecologic oncology v.147 no.3, 2017년, pp.690 - 694   SCI SCIE
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Preoperative C-reactive protein serum levels as a predictive diagnostic marker in patients with adnexal masses

Reiser, Elisabeth    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria   ); Aust, Stefanie    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria   ); Seebacher, Veronika    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria   ); Reinthaller, Alexander    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria   ); Helmy-Bader, Samir    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria   ); Schwameis, Richard    (Department of General Gynecology and Gynecologic Oncology, Gynecologic Cancer Center, Comprehensive Cancer Center Vienna, Medical University of Vienna  ); Grimm, Christoph   Polterauer, Stephan  
  • 초록  

    Abstract Objective To evaluate C-reactive protein (CRP) serum levels as a preoperative predictive marker for ovarian cancer in patients with adnexal masses. Methods CRP serum levels of 1843 adnexal masses and subsequent surgery were investigated (patients with benign ovarian tumors: n=1423; borderline tumor of the ovary [BTO]: n=83; EOC: n=337). Test characteristics and predictive values of CRP serum levels were investigated by univariate analysis and multivariate binary logistic regression models. Results Median (interquartile range) serum CRP levels in patients with benign ovarian tumors, BTO, and EOC were 0.4 (0.1–0.6)mg/dL, 0.5 (0.2–0.9)mg/dL, and 1.6 (0.5–5.4)mg/dL, respectively (p Conclusion CRP serum levels independently predicted the presence of BTO and EOC in patients with suspicious adnexal masses. CRP serum levels seem to be of additional value to CA-125 in the preoperative differential diagnosis of adnexal masses and might be particularly in combination with CA-125 clinically useful. Highlights Elevated CRP serum levels are associated with the presence of BTO and EOC. CRP is of additional value to CA-125 in preoperative diagnosis of adnexal masses. Combination of CRP and CA-125 results in a NNT of 2.11 for EOC/BTO detection. CRP and CA-125 combined improve diagnosis in pre- and postmenopausal women.


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