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Molecular and cellular neurosciences v.85, 2017년, pp.29 - 44   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cocaine modifies brain lipidome in mice

Lin, Yiyun    (National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China   ); Gu, Hui    (National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China   ); Jiang, Linhong    (National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China   ); Xu, Wei    (National Chengdu Center for Safety Evaluation of Drugs, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative Innovation Center for Biotherapy, Chengdu 610041, China   ); Liu, Chunqi    (State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Collaborative  ); Li, Yan   Qian, Xinying   Li, Dandan   Li, Zhuoling   Hu, Jing   Zhang, Huaqin   Guo, Wei   Zhao, Yinglan   Cen, Xiaobo  
  • 초록  

    Abstract Lipids are predominant components of the brain and key regulators for neural structure and function. The neuropsychopharmacological effect of cocaine has been intensively investigated; however, the impact of cocaine on brain lipid profiles is largely unknown. In this study, we used a LC-MS-based lipidomic approach to investigate the impact of cocaine on brain lipidome in two mouse models, cocaine-conditioned place preference (CPP) and hyperlocomotor models and the lipidome was profoundly modified in the nucleus accumbens (NAc) and striatum respectively. We comprehensively analyzed the lipids among 21 subclasses across 7 lipid classes and found that cocaine profoundly modified brain lipidome. Notably, the lipid metabolites significantly modified were sphingolipids and glycerophospholipids in the NAc, showing a decrease in ceramide and an increase in its up/downstream metabolites levels, and decrease lysophosphatidylcholine (LPC) and lysophosphoethanolamine (LPE) and increase phosphatidylcholine (PC) and phosphatidylethanolamines (PE) levels, respectively. Moreover, long and polyunsaturated fatty acid phospholipids were also markedly increased in the NAc. Our results show that cocaine can markedly modify brain lipidomic profiling. These findings reveal a link between the modified lipidome and psychopharmacological effect of cocaine, providing a new insight into the mechanism of cocaine addiction. Highlights Cocaine intensively modified lipidome in NAc. Cocaine mainly affected phospholipid and sphingolipid metabolism. Ceramide was decreased in NAc after cocaine administration. Cocaine increased long and polyunsaturated fatty acid phospholipids in NAc.


  • 주제어

    Cocaine .   Nucleus accumbens .   Lipidomics .   Sphingolipids .   Glycerophospholipids .   Polyunsaturated fatty acid.  

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