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Molecular and cellular neurosciences v.85, 2017년, pp.45 - 56   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

TGF-β1 enhances phagocytic removal of neuron debris and neuronal survival by olfactory ensheathing cells via integrin/MFG-E8 signaling pathway

Li, Yijian    (Corresponding authors at: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.   ); Zou, Ting    (Corresponding authors at: Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing, China.  ); Xue, Langyue   Yin, Zheng Qin   Huo, Shujia   Xu, Haiwei  
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    Abstract Olfactory ensheathing cells (OECs) have been shown to be a leading candidate in cell therapies for central nervous system (CNS) injuries and neurodegenerative diseases. Rapid clearance of neuron debris can promote neuronal survival and axonal regeneration in CNS injuries and neurodegenerative diseases. The phagocytic removal of neuron debris by OECs has been shown to contribute to neuronal outgrowth. However, the precise molecular and cellular mechanisms of phagocytic removal of neuron debris by OECs have not been explored. In this study, we found that OECs secreted anti-inflammatory cytokine transforming growth factor β1 (TGF-β1) during the phagocytic removal of neuron debris. TGF-β1 enhanced phagocytic activity of OECs through regulating integrin/MFG-E8 signaling pathway. In addition, TGF-β1 shifted OECs towards a flattened shape with increased cellular area, which might also be involved in the enhancement of phagocytic activity of OECs. Furthermore, the removal of neuron debris by OECs affected neuronal survival and outgrowth. TGF-β1 enhanced the clearance of neuron debris by OECs and increased neuronal survival. These results reveal the role and mechanism of TGF-β1 in enhancing the phagocytic activity of OECs, which will update the understanding of phagocytosis of OECs and improve the therapeutic use of OECs in CNS injuries and neurodegenerative diseases. Highlights OECs secreted TGF-β1 during the phagocytic removal of neuron debris. TGF-β1 enhanced phagocytic activity of OECs through regulating integrin/MFG-E8 pathway. TGF-β1 enhanced the clearance of neuron debris by OECs and increased neuronal survival. TGF-β1 shifted OECs towards a flattened shape.


  • 주제어

    Olfactory ensheathing cells .   Phagocytic activity .   TGF-β1 .   Integrin/MFG-E8 .   Neuronal survival.  

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