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Microbial pathogenesis v.112, 2017년, pp.156 - 163   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Synergistic effect of eugenol, carvacrol, thymol, p-cymene and γ-terpinene on inhibition of drug resistance and biofilm formation of oral bacteria

Miladi, Hanene (Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia ) ; Zmantar, Tarek (Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia ) ; Kouidhi, Bochra (College of Applied Medical Sciences, Medical Laboratory Department, Yanbu el Bahr, Taibah University, Al Madinah Al Monawarah, Saudi Arabia ) ; Al Qurashi, Yasir Mohammed A. (College of Applied Medical Sciences, Medical Laboratory Department, Yanbu el Bahr, Taibah University, Al Madinah Al Monawarah, Saudi Arabia ) ; Bakhrouf, Amina (Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Rue Avicenne, Monastir 5000, Tunisia ) ; Chaabouni, Yassine (Laboratory of Bacteriology and Molecular Biology, Hôspital of Ibn El Jazzar, Kairouan, Tunisia ) ; Mahdouani, Kacem (Laboratory of Analysis, Treatment and Valorization of Pollutants of the Environment and Products, Faculty of Pharmacy, Rue Avicenne, Monast ) ; Chaieb, Kamel ;
  • 초록  

    Abstract Dental caries remains the most prevalent oral infectious disease worldwide. In this study, the antibacterial and the antibiofilm activities of five essential oils (EO's): eugenol (EUG), carvacrol (CAR), thymol (TYH), p-cymene (CYM) and γ-terpinene (TER) were tested (alone or in combinaison with tetracycline) against oral bacteria. In addition, their potential roles to enhance the accumulation of ethidium bromide (EtBr) in bacterial cells were tested. Our results indicated that EO's induced a selective antimicrobial activity. A synergistic effect of EO's and tetracycline (TET) was noticed with a reduction rate ranged from 2 to 8-fold. In addition, the efflux of EtBr was inhibited with a decrease in loss of EtBr from the bacteria. On the other hand a significant anti-biofilm activities of EO's (alone or combined with antibiotics) was noticed. In conclusion the tested EO's may be considered as a potential natural source with a resistance-modifying activity and may be applied to eradicate bacterial biofilm. Highlights Dental caries remains a serious problem worldwide. EUG, CAR, TYH, CYM and TER displayed a synergitic effect with TET against oral pathogens. The tested EO's inhibit the efflux of EtBr from the cells. The combination of EO's and TET enhance the eradication of bacterial biofilm preformed on both polystyrene and tooth surface. EO's might be useful as an alternative approach to improve the clinical efficacy of antibiotic.


  • 주제어

    Staphylococcus aureus .   Oral strains .   Antibacterial activity .   Antibiofilm activity .   Efflux pumps inhibitors.  

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