본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental cell research v.361 no.2, 2017년, pp.292 - 299   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

CTP synthase forms the cytoophidium in human hepatocellular carcinoma

Chang, Chia-Chun (Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom ) ; Jeng, Yung-Ming (Department of Pathology, National Taiwan University Hospital, Taipei 10002, Taiwan, Republic of China ) ; Peng, Min (Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan, Republic of China ) ; Keppeke, Gerson Dierley (Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom ) ; Sung, Li-Ying (Institute of Biotechnology, National Taiwan University, Taipei 106, Taiwan, Republic of China ) ; Liu, Ji-Long (Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom ) ;
  • 초록  

    Abstract CTP synthase (CTPS) can aggregate into an intracellular macrostructure, the cytoophidium, in various organisms including human cells. Previous studies have shown that assembly of human CTPS cytoophidia may be correlated with the cellular metabolic status, and is able to promote the activity of CTPS. A correlation between the cytoophidium and cancer metabolism has been proposed but not yet been revealed. In the current study we provide clear evidence of the presence of CTPS cytoophidia in various human cancers and some non-cancerous tissues. Moreover, among 203 tissue samples of hepatocellular carcinoma, 56 (28%) samples exhibited many cytoophidia, whereas no cytoophidia were detected in adjacent non-cancerous hepatocytes for all samples. Our findings suggest that the CTPS cytoophidium may participate in the adaptive metabolism of human hepatocellular carcinoma. Highlights CTPS forms the cytoophidium in various human cancers and some non-cancerous tissues. CTPS cytoophidia are observed in HCC tissues in 28% of patient samples, but not in adjacent non-cancerous hepatocytes. HCC tissues with many CTPS cytoophidia exhibit significantly higher HSP90 level than samples expressing no CTPS cytoophidium.


  • 주제어

    CTP synthase .   Cytoophidium .   Glutamine metabolism .   Heatshock protein 90 .   Human hepatocellular carcinoma .   Nucleotide .   Protein filamentation .   Pyrimidine.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기