본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental cell research v.361 no.2, 2017년, pp.324 - 332   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Comparison of nucleus pulposus stem/progenitor cells isolated from degenerated intervertebral discs with umbilical cord derived mesenchymal stem cells

Wu, Hao    (Department of Orthopedic Surgery, The First Affiliated Hospital, Jinan University, Guangzhou 510632, China   ); Zeng, Xiaoli    (Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Jinan University, Guangzhou 510632, China   ); Yu, Jiayue    (Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Jinan University, Guangzhou 510632, China   ); Shang, Yupan    (Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Jinan University, Guangzhou 510632, China   ); Tu, Mei    (Department of Materials Science and Engineering, Jinan University, Guangzhou 510632, China   ); Cheang, Lek Hang    (Orthopedic Surgery, Centro Hospitalar Conde de Sao Januario, Macao 999078, China   ); Zhang, Jiaqing    (Department of Biochemistry and Molecular Biology, School of Preclinical Medicine, Jinan University, Guangzhou 510632, China  );
  • 초록  

    Abstract Mesenchymal stem-cell based therapies have been proposed as novel treatments for intervertebral disc (IVD) degeneration. The development of these treatment strategies, however, has been hindered by the incomplete understanding of the origin, biological properties of nucleus pulposus (NP) derived stem/progenitor cells and their effects on the IVD degeneration. The goal of this study is to explore the biological properties of NP stem/progenitor cells isolated from degenerated IVD (D-NPMSCs) regarding immunotype, proliferative capacity, multi-lineage differentiation abilities, and the expression of NP specific cell surface markers compared to human umbilical cord mesenchymal stem cells (UCMSCs). Our results indicate that although D-NPMSCs shared the mesenchymal stromal cells (MSCs) characteristics with UCMSCs, significant differences exist in phenotype signatures and biological capacities between D-NPMSCs and UCMSCs. D-NPMSCs expressed lower expression levels of CD29 and CD105, the phenotype markers of MSCs, and exhibited reduced proliferation capability and differentiation potentials, which might account for the distinct NP microenvironment and the poor capacity for disc regeneration. This study will lay a foundation for further understanding the mechanism of stem cell-based therapy for IVD degeneration. Highlights The biological properties of D-NPMSCs were investigated compared to human UCMSCs. Although they shared the MSCs characteristics, differences exist between D-NPMSCs and UCMSCs. D-NPMSCs exhibited reduced proliferation capability and differentiation potentials.


  • 주제어

    Nucleus pulposus progenitor/stem cells .   Degenerated intervertebral disc .   Proliferation capacity .   Phenotypic markers .   Differentiation.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기