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Neurobiology of learning and memory v.145, 2017년, pp.28 - 33   SCI SCIE SSCI
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

CA1 inactivation impairs episodic-like memory in rats

Drieskens, Davi Carvalho (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) ; Neves, Lívia Rodrigues (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) ; Pugliane, Karen Cristina (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) ; de Souza, Ingrid Brasilino Montenegro Bento (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) ; Lima, Álvaro da Costa (Behavioral Neuroscience Laboratory, Department of Pharmacology, Universidade Federal de São Paulo, São Paulo, SP, Brazil ) ; Salvadori, Mirian Graciela da Silva Stiebbe (Memory and Cognition Studies Laboratory, Department of Psychology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil ) ; Ribeiro, Alessandra Mussi (Laboratory of Neuroscience and Bioprospecting of Natural Products, Department of Biosciences, Universidade Federal de São Paulo, Santos, SP, Brazil ) ; Silva, Regina Helena (Behavi ) ; Barbosa, Flávio Freitas ;
  • 초록  

    Abstract Episodic memory was initially believed to be unique to humans. However, studies demonstrate that nonhuman species discriminate items based on the triad what, where and when . Here we addressed the role of the dorsal hippocampal subfield CA1 in an integrative what-where-when task in Wistar rats. We performed bilateral inactivation of dorsal CA1 with the GABA A agonist muscimol previously to the task. As expected, sham-operated animals recollected an integrative memory for objects (what), their places (where) and temporal order (when). However, the inactivation of CA1 impaired the performance of the three components of episodic-like memory. In addition, total time of objects exploration and distance traveled were not different between groups, indicating that rats had similar levels of motivation, thus, alterations in exploration does not account for impaired locomotor performance. Altogether, our data provides evidence that CA1 plays an important role in episodic-like memory. Highlights Rats recollected an integrated episodic-like memory. Rats hippocampus was bilaterally inactivated with muscimol previously to the task. The inactivation of CA1 impaired the recollection of episodic-like memory. Our data provides evidence that CA1 plays an essential role in episodic-like memory.


  • 주제어

    Episodic-like memory .   CA1 .   Muscimol .   Wistar rats.  

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