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Environmental research v.160, 2018년, pp.347 - 352   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Molecular characterization of Cryptococcus neoformans and Cryptococcus gattii from environmental sources and genetic comparison with clinical isolates in Apulia, Italy

Montagna, Maria Teresa    (Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy   ); De Donno, Antonella    (Department of Biological and Environmental Science and Technology, University of Salento, Lecce, Italy   ); Caggiano, Giuseppina    (Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy   ); Serio, Francesca    (Department of Biological and Environmental Science and Technology, University of Salento, Lecce, Italy   ); De Giglio, Osvalda    (Department of Biomedical Science and Human Oncology, University of Bari 'Aldo Moro', Bari, Italy   ); Bagordo, Francesco    (Department of Biological and Environmental Science and Technology, University of Salento, Lecce, Italy   ); D'Amicis, R.    (Department of Biomedical Sciences for Health, Università  ); Lockhart, Shawn R.    (degli Studi di Milano, Milano, Italy   ); Cogliati, Massimo    (Fungal Reference Laboratory, Centers for Disease Control and Prevention, Atlanta, GA, USA   );
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    Abstract The present study investigated the environmental distribution of Cryptococcus neoformans and C. gattii species complex molecular types, mating types and sequence types in Apulia, a region of Southern Italy. A total of 2078 specimens from arboreal and animal sources were analyzed. The percentage of positive samples was similar among both arboreal and animal specimens: 4.2% vs. 5.1% for C. neoformans species complex and 0.6% vs. 1.4% for C. gattii species complex. Molecular typing identified 78 isolates as VNI (76 αA and two aA), one as AD-hybrid αADa, and 16 as VGI aB. VNI isolates presented 10 different sequence types (STs) and VGI isolates two. The most frequent STs among C. neoformans and C. gattii species complex isolates were ST23 (51%) and ST156 (90%), respectively. Comparison with molecular types and STs results obtained from 21 clinical isolates collected in Apulia showed that one C. neoformans VNI clinical isolate shared an identical sequence type of one arboreal isolate (ST61) and that one C. gattii VGI clinical isolate matched with the main ST (ST156) present in the environment. In addition, molecular type VNIV was found only among clinical isolates and was absent in the investigated environmental area. In conclusion, the present study identified which C. neoformans and C. gattii species complex genotypes are circulating in Apulia, defined their ecological niches and revealed the relationship with clinical cases. It represents a basal study for addressing future investigations and public health interventions in the region. Highlights Meta-analysis of data recorded during environmental surveys of Cryptococcus spp in Apulia. Olive trees can be an alternative ecological niche for C. neoformans and C. gattii . Correlation clinical cases with possible new environmental sources of infection.


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