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Environmental research v.160, 2018년, pp.97 - 106   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Prenatal exposure to mercury and longitudinally assessed fetal growth: Relation and effect modifiers

Ballester, Ferran (Nursing School, Universitat de València, Valencia, Spain ) ; Iñiguez, Carmen (FISABIO–Universitat Jaume I–Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain ) ; Murcia, Mario (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Guxens, Mònica (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Basterretxea, Mikel (Public Health Division of Gipuzkoa, San Sebastián, Spain ) ; Rebagliato, Marisa (FISABIO–Universitat Jaume I–Universitat de València Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain ) ; Vioque, Jesús (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Lertxundi, Aitana (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Fernandez-Somoano, Ana (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Tardon, Adonina (Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Spain ) ; Sunyer, Jordi (Spanish Consortium for Research on Epidemiolog ) ; Llop, Sabrina ;
  • 초록  

    Abstract Background Prenatal mercury exposure has been related to reductions in anthropometry at birth. Levels of mercury have been reported as being relatively elevated in the Spanish population. Objective To investigate the relation between prenatal exposure to mercury and fetal growth. Methods Study subjects were pregnant women and their newborns (n:1867) participating in a population-based birth cohort study set up in four Spanish regions from the INMA Project. Biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), and estimated fetal weight (EFW) were measured by ultrasounds at 12, 20, and 34 weeks of gestation. Size at and growth between these points were assessed by standard deviation (SD) scores adjusted for constitutional characteristics. Total mercury (T-Hg) was determined in cord blood. Associations were investigated by linear regression models, adjusted by sociodemographic, environmental, nutritional – including four seafood groups – and lifestyle-related variables in each sub-cohort. Final estimates were obtained using meta-analysis. Effect modification by sex, seafood intake and polychlorinated biphenyl (PCB) congener 153 concentration was assessed. Results Geometric mean of cord blood T-Hg was 8.2μg/L. All the estimates of the association between prenatal Hg and growth from 0 to 12 weeks showed reductions in SD-scores, which were only statistically significant for BPD. A doubling of cord blood T-Hg was associated with a 0.58% reduction in size of BPD at week 12 (95% confidence interval -CI-: − 1.10, − 0.07). Size at week 34 showed estimates suggestive of a small reduction in EFW, i.e., a doubling of T-Hg levels was associated with a reduction of 0.38% (95% CI: − 0.91, 0.15). An interaction between PCB153 and T-Hg was found, with statistically significant negative associations of T-Hg with AC and EFW in late pregnancy among participants with PCB153 below the median. Conclusions Exposure to mercury during pregnancy was associated with early reductions in BPD. Moreover, an antagonism with PCB 153 was observed with noteworthy reductions late in pregnancy in AC and EFW in the group with lower PCB153. Highlights The largest of two studies on the relation between mercury exposure and fetal growth. Study on pregnant women from a general population exposed to relatively elevated mercury levels. Mercury exposure associated with decreased biparietal diameter early in pregnancy. An antagonism between PCB153 and mercury was found. Higher decreases in fetal parameters were observed in fetuses with lower PCB153.


  • 주제어

    Pregnancy .   Mercury .   Fetal growth .   Seafood consumption .   Polychlorinated biphenyl 153.  

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