본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Environmental research v.160, 2018년, pp.506 - 513   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Combined effects of prenatal exposure to polycyclic aromatic hydrocarbons and material hardship on child ADHD behavior problems

Perera, Frederica P. (Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Wheelock, Kylie (Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Wang, Ya (Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Tang, Deliang (Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Margolis, Amy E. (Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Badia, Gladys (Columbia Center for Children's Environmental Health, Mailman School of Public Health, Columbia University, 722W. 168th Street, New York, NY 10032, USA ) ; Cowell, Whitney (Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722W. 1 ) ; Miller, Rachel L. ; Rauh, Virginia ; Wang, Shuang ; Herbstman, Julie B. ;
  • 초록  

    Abstract Importance Polycyclic aromatic hydrocarbons (PAH) are carcinogenic and neurotoxic combustion by-products commonly found in urban air. Exposure to PAH is disproportionately high in low income communities of color who also experience chronic economic stress. Objective In a prospective cohort study in New York City (NYC) we previously found a significant association between prenatal PAH exposure and Attention Deficit Hyperactivity Disorder (ADHD) behavior problems at age 9. Here, we have evaluated the joint effects of prenatal exposure to PAH and prenatal/childhood material hardship on ADHD behavior problems. Materials and Methods We enrolled nonsmoking African-American and Dominican pregnant women in New York City between 1998 and 2006 and followed their children through 9 years of age. As a biomarker of prenatal PAH exposure, PAH-DNA adducts were measured in maternal blood at delivery and were dichotomized at the limit of detection (to indicate high vs. low exposure). Maternal material hardship (lack of adequate food, housing, utilities, and clothing) was self-reported prenatally and at multiple time points through child age 9. Latent variable analysis identified four distinct patterns of hardship. ADHD behavior problems were assessed using the Conners Parent Rating Scale- Revised. Analyses adjusted for relevant covariates. Results Among 351 children in our sample, across all hardship groups, children with high prenatal PAH exposure (high adducts) generally had more symptoms of ADHD (higher scores) compared to those with low PAH exposure. The greatest difference was seen among the children with hardship persisting from pregnancy through childhood. Although the interactions between high PAH exposure and hardship experienced at either period (“persistent” hardship or “any” hardship) were not significant, we observed significant differences in the number of ADHD symptoms between children with high prenatal PAH exposure and either persistent hardship or any hardship compared to the others. These differences were most significant for combined high PAH and persistent hardship: ADHD Index (p Conclusion The present findings add to existing evidence that co-exposure to socioeconomic disadvantage and air pollution in early life significantly increases the risk of adverse neurodevelopmental outcomes. They suggest the need for multifaceted interventions to protect pregnant mothers and their children. Highlights PAH are common carcinogenic and neurotoxic combustion-related air pollutants. Exposure to PAH tends to be disproportionately high in low income communities. Prenatal PAH exposure was measured by PAH-DNA adducts in maternal blood. We evaluated the combined effects of prenatal PAH and material hardship on ADHD. We observed significant effects of combined exposures on ADHD behavior problems.


  • 주제어

    Air pollution .   PAH .   ADHD .   Prenatal .   Adducts .   Material hardship.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기