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Virology v.513, 2018년, pp.180 - 187   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs

Kincaid, Rodney P. (Department of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America ) ; Panicker, Neena G. (Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Tawam Hospital Complex, P.O. Box 17666, Al Ain, United Arab Emirates ) ; Lozano, Mary M. (Department of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America ) ; Sullivan, Christopher S. (Department of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America ) ; Dudley, Jaquelin P. (Department of Molecular Biosciences, The University of Texas at Austin, 100 East 24th Street, NHB 2.616, Austin, TX, United States of America ) ; Mustafa, Farah (Department of Biochemistry, College of Medicine and Health Sciences, UAE University, Tawam Hospital Complex, P.O. Box 17666, Al Ain, United Arab Emirates ) ;
  • 초록  

    Abstract Mouse mammary tumor virus (MMTV) induces breast cancer in mice in the absence of known virally-encoded oncogenes. Tumorigenesis by MMTV is thought to occur primarily through insertional mutagenesis, leading to the activation of cellular proto-oncogenes and outgrowth of selected cells. Here we investigated whether MMTV encodes microRNAs (miRNAs) and/or modulates host miRNAs that could contribute to tumorigenesis. High throughput small RNA sequencing analysis of MMTV-infected cells and MMTV-induced mammary tumors demonstrates that MMTV does not encode miRNAs. However, infected tissues have altered levels of several host miRNAs, including increased expression of members of the oncogenic miRNA cluster, miR-17–92. Notably, similar changes in miRNA levels have been previously reported in human breast cancers. Combined, our results demonstrate that virally encoded miRNAs do not contribute to MMTV-mediated tumorigenesis, but that changes in specific host miRNAs in infected cells may contribute to virus replication and tumor biology. Highlights The MMTV genome does not encode viral miRNAs. MMTV infection alters host miRNA levels, including the oncogenic miR-17–92 cluster. Host miRNA changes following MMTV infection occur prior to tumor formation. MMTV-induced changes to host miRNAs may help drive tumor initiation/maintenance. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Retroviruses .   Mouse mammary tumor virus (MMTV) .   Breast cancer .   Virus-host interactions .   microRNAs (miRNAs) .   miR-17–92 cluster.  

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