본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Virology v.513, 2018년, pp.91 - 97   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Soybean-derived Bowman-Birk inhibitor (BBI) blocks HIV entry into macrophages

Ma, Tong-Cui (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ; Le Guo, Tong-Cui (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ; Zhou, Run-Hong (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ; Wang, Xu (Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA ) ; Liu, Jin-Biao (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ; Li, Jie-Liang (Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA ) ; Zhou, Yu (Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, Philadelphia, PA 19140, USA ) ; Hou, Wei (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ; Ho, Wen-Zhe (Wuhan University School of Basic Medical Sciences, Wuhan, Hubei 430071, PR China ) ;
  • 초록  

    Abstract Bowman-Birk inhibitor (BBI) is a soybean-derived protease inhibitor that has anti-inflammation and anti-HIV effect. Here, we further investigated the anti-HIV action of BBI in macrophages, focusing on its effect on viral entry. We found that BBI could significantly block HIV entry into macrophages. Investigation of the mechanism(s) of the BBI action on HIV inhibition showed that BBI down-regulated the expression of CD4 receptor (as much as 80%) and induced the production of the CC chemokines (up to 60 folds at protein level) in macrophages. This inhibitory effect of BBI on HIV entry could be blocked by the neutralization antibodies to CC chemokines. These findings indicate that BBI may have therapeutic potential as a viral entry inhibitor for the prevention and treatment of HIV infection. Highlights BBI blocks HIV entry into macrophages. BBI down-regulates the expression of CD4 and CCR5. BBI up-regulates CC chemokines expression.


  • 주제어

    Bowman-Birk inhibitor .   HIV .   CD4 .   CCR5 .   CC chemokine.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기