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Pulmonary pharmacology & therapeutics v.47, 2017년, pp.9 - 15   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Central mechanisms of airway sensation and cough hypersensitivity

Driessen, Alexandria K.    (Department of Anatomy and Neuroscience, The University of Melbourne, Australia   ); McGovern, Alice E.    (Department of Anatomy and Neuroscience, The University of Melbourne, Australia   ); Narula, Monica    (School of Biomedical Sciences, The University of Queensland, Australia   ); Yang, Seung-Kwon    (School of Biomedical Sciences, The University of Queensland, Australia   ); Keller, Jennifer A.    (School of Biomedical Sciences, The University of Queensland, Australia   ); Farrell, Michael J.    (Biomedicine Discovery Institute and Department of Medical Imaging and Radiation Sciences, Monash University, Australia   ); Mazzone, Stuart B.    (Department of Anatomy and Neuroscience, The University of Melbourne, Australia  );
  • 초록  

    Abstract The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory behaviours in response to sensing an airway irritation. Disordered sensory processing is a hallmark feature of many pulmonary disorders and results in the development of cough hypersensitivity syndrome, characterised by chronic cough and a persistent urge-to-cough in affected individuals. However, the mechanism underpinning how the airway sensory circuits become disordered, especially at the level of the central nervous system, is not well understood. In this mini-review we present well-defined mechanisms that lead to the development of chronic pain as a framework to explore the evidence that cough disorders may manifest due to neuroplasticity and sensitisation of important components of the airway sensory circuitry in the brain. We highlight recent discoveries of how airway sensory processing occurs in the brain in health and disease and additionally suggest areas where gaps exist in our current knowledge on the topic, with the goal of providing a better understanding of how airway circuits become dysfunctional in disease. This may in turn help identify novel therapeutic targets for restoring normal airway sensory processing and alleviating excessive cough.


  • 주제어

    Central sensitization .   Vagal afferents .   Brainstem .   Descending inhibition .   Neuroinflammation .   fMRI.  

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