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Journal of colloid and interface science v.512, 2018년, pp.439 - 445   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Ag-HPBs by a coating-etching strategy and their derived injectable implants for enhanced tumor photothermal treatment

Su, Yun Yan (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Yao, Hui (Department of General Surgery, The First Hospital Affiliated to Soochow University, Suzhou 215006, PR China ) ; Zhao, Shuang (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Tian, Wei (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Liu, Wen Fei (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Wang, Shou Ju (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Liu, Ying (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Tian, Ying (Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nangjing 210002, PR China ) ; Zhang, Xiao Dong (Department of Medical Imaging, Jinling Hospital, School of Medicine, Na ) ; Teng, Zhao Gang ; Lu, Guang Ming ; Zhang, Long Jiang ;
  • 초록  

    Abstract Herein, we demonstrate a coating-etching strategy to directly synthesize hollow Prussian blue (PB) nanocubes with well-dispersed Ag nanoparticles (denoted as Ag-HPB). The method is accomplished by introduction of PB precursors, K 3 Fe(CN) 6 and Fe 3+ into a reaction system containing AgNO 3 and ascorbic acid, in which a series reactions contain formation of Ag nanoparticles, coating of PB on the nanoparticles, and diffusion of Ag into the PB frameworks occur. The strategy for preparation of the hollow structured Ag-HPB is intrinsically simple and does not require pre-preparation of any sacrificial templates or toxic etching agents. The obtained Ag-HPB nanocubes possess uniform size (69 nm), well-defined hollow structure, strong near-infrared photothermal conversion capacity, and excellent photoacoustic and magnetic resonance imaging abilities. Furthermore, an injectable photothermal implants are prepared for the first time by mixing the Ag-HPB nanocubes with clinically used biological glue, which significantly enhance photothermal anti-tumor efficacy, showing great potential for clinical tumor treatment. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Prussian blue .   Hollow structure .   Coating-etching strategy .   Injectable implants .   Photothermal treatment.  

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