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NeuroImage v.162, 2017년, pp.249 - 256   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Impact of tissue correction strategy on GABA-edited MRS findings

Porges, Eric C. (Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32608, USA ) ; Woods, Adam J. (Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32608, USA ) ; Lamb, Damon G. (Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32608, USA ) ; Williamson, John B. (Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32608, USA ) ; Cohen, Ronald A. (Center for Cognitive Aging and Memory (CAM), McKnight Brain Institute, Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, 32608, USA ) ; Edden, Richard A.E. (Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA ) ; Harris, Ashley D. (Department o ) ;
  • 초록  

    Abstract Tissue composition impacts the interpretation of magnetic resonance spectroscopy metabolite quantification. The goal of applying tissue correction is to decrease the dependency of metabolite concentrations on the underlying voxel tissue composition. Tissue correction strategies have different underlying assumptions to account for different aspects of the voxel tissue fraction. The most common tissue correction is the CSF-correction that aims to account for the cerebrospinal fluid (CSF) fraction in the voxel, in which it is assumed there are no metabolites. More recently, the α-correction was introduced to account for the different concentrations of GABA+in gray matter and white matter. In this paper, we show that the selected tissue correction strategy can alter the interpretation of results using data from a healthy aging cohort with GABA+ measurements in a frontal and posterior voxel. In a frontal voxel, we show an age-related decline in GABA+ when either no tissue correction (R 2 = 0.25, p 2 = 0.08, p 2 = 0.02, p = 0.15). However, with the α-correction we still find that cognitive performance is correlated with GABA+ (R 2 = 0.11, p Highlights The selection of tissue correction approach can fundamentally impact the interpretation of GABA+ results. In the frontal region, overall tissue volume decreases with age but GABA+ in the remaining tissue does not decrease with age. In frontal regions, GABA+ correlates with MoCA, a marker of cognitive function. This work support the use of the α-correction for GABA+ -MRS.


  • 주제어

    α-correction .   Aging .   Atrophy .   CSF-correction .   GABA .   GABA-edited MRS .   Gray matter .   Tissue-correction .   White matter.  

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