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Human pathology v.69, 2017년, pp.1 - 7   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Genetic profile of ductal adenocarcinoma of the prostate

Seipel, Amanda H. (Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden ) ; Whitington, Thomas (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden ) ; Delahunt, Brett (Department of Pathology and Molecular Medicine, Wellington School of Medicine and Health Sciences, University of Otago, Wellington 6021, New Zealand ) ; Samaratunga, Hemamali (Aquesta Pathology, Brisbane, Queensland 4066, Australia ) ; Mayrhofer, Markus (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden ) ; Wiklund, Peter (Department of Urology, Division of Surgery, Karolinska University Hospital, 171 76 Stockholm, Sweden ) ; Grönberg, Henrik (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden ) ; Lindberg, Johan (Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden ) ; Egevad, Lars (Department of Oncology-Pathology, Karolinska Institutet, 171 76 Stockholm, Sweden ) ;
  • 초록  

    Summary Despite being discovered almost 50 years ago, little is known regarding the genetic profile of ductal adenocarcinoma of the prostate (DAC). In recent years, progress has been made in the understanding of the genetics of acinar adenocarcinomas, and at least 7 genetically different subtypes have been identified. DAC is known to present at an advanced stage with a high rate of extraprostatic extension and seminal vesicle invasion, and a decreased interval to biochemical recurrence and the development of metastatic disease when compared with acinar adenocarcinoma. Our aim was to investigate the genetic profile of DAC to determine whether there is a genomic rationale for the aggressive behavior associated with this tumor type. Frozen tissue from 11 cases of DAC with paired benign tissue was analyzed. After DNA extraction, copy-number alteration analysis was performed, as well as identification of mutations and indels. We compared the fraction of the DAC genome with copy-number alteration to previous results from 74 primary acinar adenocarcinomas of the prostate. The alteration rate in DAC was comparable to that of acinar adenocarcinoma of high Gleason score. DAC harbored somatic changes seen in advanced and/or metastatic castration-resistant acinar adenocarcinoma, which likely accounts for its aggressive biological behavior. Highlights The genetic profile of ductal adenocarcinoma of the prostate was investigated. The genetic alteration rate was comparable to high-grade acinar adenocarcinoma. The involved genes were similar to those affected in advanced prostate cancer. Our findings may explain the aggressive behavior of ductal adenocarcinom.


  • 주제어

    Prostatectomy .   Pathology .   Prostate cancer .   Adenocarcinoma .   Ductal cancer .   Genetics.  

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