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Human pathology v.69, 2017년, pp.55 - 62   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Primary sclerosing cholangitis is protective against nonalcoholic fatty liver disease in inflammatory bowel disease

Bosch, Dustin E.    (Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195   ); Yeh, Matthew M.    (Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195  );
  • 초록  

    Summary Nonalcoholic fatty liver disease (NAFLD) occurs with higher prevalence in patients with inflammatory bowel disease (IBD) relative to the general population, and susceptibility is related to the metabolic syndrome, as well as higher prevalence of bowel resection and gut microbiotal factors. Liver complications, including NAFLD and primary sclerosing cholangitis (PSC), contribute to treatment and prognosis of patients with IBD. However, the potential interplay of NAFLD and PSC is not well understood. We retrospectively assessed severity of steatosis and steatohepatitis in liver specimens from 49 patients with IBD only, 44 with IBD and comorbid PSC, and 30 with IBD and PSC after liver transplantation. Patients with IBD had higher prevalence of at least grade 1 steatosis (59%) than IBD and PSC (11%), or IBD and PSC posttransplant (3%) ( P P P = .01). Despite these differences in susceptibility to NAFLD, the 3 populations had statistically indistinguishable average body mass index and total cholesterol and prevalence of hypertension, diabetes, and alcohol use. Multivariate regression modeling revealed body mass index, hypertension, and diabetes as significant correlates to NAFLD severity in all studied populations. In conclusion, patients with comorbid IBD and PSC have significantly less susceptibility to NAFLD than those with IBD alone, despite similar prevalence of major NAFLD risk factors. Highlights Patients with IBD ± PSC have similar metabolic syndrome risk factors. Comorbid PSC is associated with reduced NAFLD. Protection against NAFLD persists after orthotopic liver transplant.


  • 주제어

    Steatohepatitis .   Steatosis .   Metabolic syndrome .   Liver transplant .   Primary sclerosing cholangitis.  

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