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Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus v.21 no.6, 2017년, pp.499 - 501.e1   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Macular morphology following unilateral bevacizumab injection for retinopathy of prematurity: an OCT study

Clark, Antony    (Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada   ); Wright, Tom    (Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada   ); Isaac, Maram    (Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada   ); Westall, Carol    (Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada   ); Mireskandari, Kamiar    (Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, Toronto, Ontario, Canada   ); Tehrani, Nasrin N.    (University of Toronto, Toronto, Ontario, Canada  );
  • 초록  

    This retrospective case series assessed the influence of unilateral intravitreal bevacizumab (IVB) for unilateral type 1 retinopathy of prematurity (ROP) on macular thickness and foveal development. Seven infants with unilateral type 1 ROP were treated with intravitreal bevacizumab 0.625 mg/0.025 ml in one eye only. To determine whether macular thickness and fovea structural development were affected by treatment, spectral domain optical coherence tomography was performed on both treated and untreated eyes. The mean gestational age of infants was 25.3 ± 0.3 weeks; the mean birth weight, 776 ± 17.6 g. Treatment was given at a mean postmenstrual age of 37.2 ± 0.4 weeks. Foveal development was normal in 3 (43%) treated versus 5 (71%) untreated eyes. The mean central foveal thickness for treated and untreated eyes was 270.1 μm ± 19.6 and 253.0 μm ± 27.2 respectively ( P = 0.15). There was small but nonsignificant difference in foveal development and thickness in eyes treated with intravitreal bevacizumab compared to fellow eyes. This study generates important data to test the hypothesis that foveal thickness is greater in unilateral type 1 ROP eyes treated with IVB compared to untreated fellow eyes.


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