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Comprehensive psychiatry v.80, 2018년, pp.24 - 33   SCI SCIE SSCI
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cognitive outcomes in prenatal methamphetamine exposed children aged six to seven years

Kwiatkowski, Maja A.    (ACSENT Laboratory, Department of Psychology, University of Cape Town, Rondebosch 7700, South Africa   ); Donald, Kirsten A.    (Department of Paediatrics and Child Health, Institute of Child Health Building, Red Cross Memorial Childrens Hospital, Klipfontein Road, Rondebosch 7700, South Africa   ); Stein, Dan J.    (Department of Psychiatry and Mental Health, University of Cape Town, J-Block Groote Schuur Hospital, Observatory, 7925, South Africa   ); Ipser, Jonathan    (Department of Psychiatry and Mental Health, University of Cape Town, J-Block Groote Schuur Hospital, Observatory, 7925, South Africa   ); Thomas, Kevin G.F.    (ACSENT Laboratory, Department of Psychology, University of Cape Town, Rondebosch 7700, South Africa   ); Roos, Annerine    (SU/UCT MRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, Stellenbosch University, PO Box 241, Cape Town 8000, South Africa  );
  • 초록  

    Abstract Background Methamphetamine use among pregnant women has become a significant problem. Research delineating the cognitive outcomes of prenatal methamphetamine exposure (PME) in early childhood is limited, however. The aim of this study was to examine effects of PME on cognition in six-to-seven-year-old children. Methods PME children ( n = 23) and unexposed controls ( n = 22) completed a battery of neurocognitive tests, which included the Kaufman Assessment Battery for Children, Boston Naming Test, Beery Developmental Test of Visual-Motor Integration, and Grooved Pegboard Test. Results Independent samples t -tests revealed that PME children scored significantly worse than controls on the measures of IQ, learning and memory, confrontation naming, visual-motor integration, and fine motor coordination. Hierarchical regression analyses that included potential confounding sociodemographic, co-exposure and anthropometric variables confirmed that PME impacts negatively on cognitive performance. Conclusions The study confirms that PME has deleterious effects on cognition in several broad cognitive domains, likely by altering underlying brain circuitry in development. These effects may be particularly pronounced at the time when children enter formal schooling. Extended follow-ups into late childhood might help elucidate the developmental trajectory of cognitive dysfunction in PME, and subsequent effects on everyday functioning.


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