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The American heart journal v.195, 2018년, pp.39 - 49   SCI SCIE
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Global geographical variation in patient characteristics in percutaneous coronary intervention clinical trials: A systematic review and meta-analysis

Liu, Eden (Division of Cardiology, University of Illinois at Chicago, Chicago, IL ) ; Hsueh, Leon (Division of Cardiology, University of Illinois at Chicago, Chicago, IL ) ; Kim, Hajwa (The University of Illinois at Chicago, Center for Clinical and Translational Science (CCTS), Chicago, IL ) ; Vidovich, Mladen I. (Division of Cardiology, University of Illinois at Chicago, Chicago, IL ) ;
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    Background We sought to determine whether there are differences in enrolled patients' risk factors in published percutaneous coronary intervention (PCI) trials between various continents. Methods We systematically identified clinical trials evaluating PCI interventions through PubMed. We reviewed 701 studies between 1990 and 2014 from North America (N=135), Europe (N=403), and Asia (N=163), examining the prevalence of cardiovascular risk factors—hypertension (HTN), diabetes mellitus (DM), hyperlipidemia (HL), smoking, sex, and body mass index. We performed meta-regression with random- and mixed-effects models to compare patient baseline characteristics between continents and linear meta-regression analysis to test trends over time. Results In meta-regression with random-effects model, North American trials recruited the lowest proportion of male participants (71.32%), followed by Asian (74.41%) and European trials (76.47%; P P = .0035) and HL (63.72%, P P P = .0144). When adjusting for other moderators such as publication date, body mass index, and sex in meta-regression with mixed-effects model, age was significantly positively correlated with HTN, HL, DM, and smoking ( P Conclusions There are major continental differences in risk factors among patients enrolled in PCI trials from various continents. Clinical trial results may not be applicable to patient populations from another region.


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