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Osteoarthritis and cartilage v.26 no.1, 2018년, pp.95 - 107   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Variable cartilage degradation in mice with diet-induced metabolic dysfunction: food for thought

Kozijn, A.E.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Gierman, L.M.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); van der Ham, F.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Mulder, P.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Morrison, M.C.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Kühnast, S.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); van der Heijden, R.A.    (Department of Pathology and Medical Biology, UMC Groningen, Groningen, The Netherlands   ); Stavro, P.M.    (Bunge North America, Saint Louis, United States   ); van Koppen, A.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Pieterman, E.J.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); van den Hoek, A.M.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Kleemann, R.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Princen, H.M.G.    (Metabolic Health Research, TNO, Leiden, The Netherlands   ); Mastbergen, S.C.    (Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands   ); Lafeber, F.P.J.G.    (Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht University, Utrecht, The Netherlands   ); Zuurmond, A.-M.    (Met  ); Bobeldijk, I.   Weinans, H.   Stoop, R.  
  • 초록  

    Summary Objective Human cohort studies have demonstrated a role for systemic metabolic dysfunction in osteoarthritis (OA) pathogenesis in obese patients. To explore the mechanisms underlying this metabolic phenotype of OA, we examined cartilage degradation in the knees of mice from different genetic backgrounds in which a metabolic phenotype was established by various dietary approaches. Design Wild-type C57BL/6J mice and genetically modified mice (hCRP, LDLr −/− . Leiden and ApoE*3Leiden.CETP mice) based on C57BL/6J background were used to investigate the contribution of inflammation and altered lipoprotein handling on diet-induced cartilage degradation. High-caloric diets of different macronutrient composition (i.e., high-carbohydrate or high-fat) were given in regimens of varying duration to induce a metabolic phenotype with aggravated cartilage degradation relative to controls. Results Metabolic phenotypes were confirmed in all studies as mice developed obesity, hypercholesteremia, glucose intolerance and/or insulin resistance. Aggravated cartilage degradation was only observed in two out of the twelve experimental setups, specifically in long-term studies in male hCRP and female ApoE*3Leiden.CETP mice. C57BL/6J and LDLr −/− . Leiden mice did not develop HFD-induced OA under the conditions studied. Osteophyte formation and synovitis scores showed variable results between studies, but also between strains and gender. Conclusions Long-term feeding of high-caloric diets consistently induced a metabolic phenotype in various C57BL/6J (-based) mouse strains. In contrast, the induction of articular cartilage degradation proved variable, which suggests that an additional trigger might be necessary to accelerate diet-induced OA progression. Gender and genetic modifications that result in a humanized pro-inflammatory state (human CRP) or lipoprotein metabolism (human-E3L.CETP) were identified as important contributing factors.


  • 주제어

    Osteoarthritis .   Metabolic dysfunction .   High-fat diet .   Obesity .   Mouse model.  

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