Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study
Abstract Objective We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). Methods Participants with body mass index (BMI) 1 %), forced vital capacity (FVC %) and restrictive respiratory defect (FEV 1 /FVC ratio > low limits of normal and FVC % Results Of 16186 participants (mean age 61.4 ± 7.2 years; 74.0% women), 116 (0.7%) had only general obesity (BMI ≥28 kg/m 2 ), 4079 (25.2%) had only central obesity (WC: ≥90 cm in men, ≥80 cm in women) and 1591 (9.8%) had both central obesity and general obesity. Comparing to those with neither central nor general obesity, those with only central adiposity and with both central and general obesity had lower pulmonary function (adjusted β range from -2.85 to -6.02 for FEV 1 % and FVC%, adjusted OR range from 1.14 to 1.70, all P 1 % and FVC%, crude OR range from 0.68 to 0.93, all P > 0.05). Both FEV 1 % and FVC% decreased per standard deviation increase in obesity indices (adjusted β from -0.46 to -3.17, all P Conclusion Central adiposity and its indices, but not general adiposity and BMI, were independently associated with lower pulmonary function and higher risk of restrictive respiratory defect in older Chinese. Highlights Those with central obesity had lower lung function, independent of general obesity. Those with only general obesity had better but non-significant pulmonary function. General and central obesity indices inversely associated with lower lung function. Adjustment for WC reversed the inverse association between BMI and lung function. Central but not general obesity was independently associated with lower lung function.
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