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Respiratory medicine v.132, 2017년, pp.132 - 138   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Prevalence of comorbidities in COPD patients by disease severity in a German population

Greulich, Timm (Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), 35043 Marburg, Germany ) ; Weist, Benjamin J.D. (HGC GesundheitsConsult GmbH, 40470 Düsseldorf, Germany ) ; Koczulla, Andreas Rembert (Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), 35043 Marburg, Germany ) ; Janciauskiene, Sabina (Department of Respiratory Medicine, Hannover Medical School, Biomedical Research in End Stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), 30625 Hannover, Germany ) ; Klemmer, Andreas (Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Centre Giessen and Marburg, Philipps-University, Member of the German Centre for Lung Research (DZL), 35043 Marburg, Germany ) ; Lux, Wolfram (HGC GesundheitsConsult GmbH, 40470 Düsseldorf, Germany ) ; Alter, Peter (Department of Medicine, Pulmona ) ; Vogelmeier, Claus F. ;
  • 초록  

    Abstract Chronic obstructive pulmonary disease (COPD) is commonly associated with multiple comorbidities. Our objective was to assess the prevalence of comorbidities in patients with COPD and to relate their prevalence to the severity of the disease by using a large German health care database. Based on the retrospective analysis of a two-year (2013–2014) database from the German Statutory Health Insurance system, we obtained a representative sample of 4,075,493 german insurants. This sample included 146,141 patients with COPD (age: ≥35 years). To these patients, we matched 1:1 by age and gender randomly selected non-COPD controls. We assessed the comorbidities and the use of cardiovascular drugs, and examined COPD subgroups according to lung function (ICD-10-coded FEV1) and the treatment with long-acting inhaled bronchodilators. Compared to non-COPD, patients with COPD had a higher prevalence of hypertension, congestive heart failure, diabetes, gastroesophageal reflux disease, chronic kidney disease, osteoporosis, psychiatric disease and lung cancer, and used more cardiovascular-related drugs. However, the prevalence of comorbidities did not correlate to the severity of airflow limitation. The results of this sizeable nationwide survey support the concept that individuals with COPD need careful evaluation regarding comorbidities. This can already be of relevance in patients with mild to moderate airflow limitation. Take home message Comorbidities in COPD have a complex relationship with disease severity, requiring a comprehensive therapy approach. Highlights The severity-dependent prevalence of comorbidities in COPD can be analysed using large health care databases. Compared to age- and gender-matched non-COPD, COPD patients have a higher prevalence of a wide variety of comorbidities. The prevalence of comorbidities is not correlated to the severity of airflow limitation. Individuals with COPD need careful evaluation regarding comorbidities, irrespective of the severity of airflow limitation.


  • 주제어

    Chronic obstructive pulmonary disease .   COPD .   Comorbidities .   Cardiovascular .   Musculoskeletal .   Diabetes .   Psychiatric disease .   Cancer.  

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