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Respiratory medicine v.132, 2017년, pp.154 - 160   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Health-related quality of life in asthma patients - A comparison of two cohorts from 2005 and 2015

Sundh, Josefin (Department of Respiratory Medicine, School of Medical Sciences, Örebro University, Örebro, Sweden ) ; Wireklint, Philip (School of Medical Sciences, Örebro University, Örebro, Sweden ) ; Hasselgren, Mikael (School of Medical Sciences, Örebro University, Örebro, Sweden ) ; Montgomery, Scott (Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden ) ; Ställberg, Björn (Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden ) ; Lisspers, Karin (Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden ) ; Janson, Christer (Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden ) ;
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    Abstract Introduction The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma. Material and methods Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t -test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015. Multivariable linear regression analyzed associations with mini-AQLQ scores. Results The mean Mini-AQLQ scores were unchanged between 2005 and 2015 (adjusted means (95% CI) 2005: 5.39 (5.27–5.33) and in 2015: 5.44 (95% CI 5.32 to 5.38), p = 0.26). Overweight (regression coefficient 95% CI) (0.21 (−0.36 to −0.07)), obesity (−0.34 (−0,50 to −0.18)), one or more exacerbations during the previous six months (−0.64 (−0.79 to −0.50)), self-rated moderate/severe disease (−1.02 (−1.15 to −0.89)), heart disease (−0.42 (−0.68 to −0.16)), anxiety/depression (−0.31 (−0.48 to −0.13)) and rhinitis (−0.25 (−0.42 to −0.08)) were associated with lower HRQL. Higher educational level (0.32 (0.19–0.46)) and self-reported knowledge of self-management of exacerbations (0.35 (0.19–0.51)) were associated with higher HRQL. Conclusions HRQL in Swedish patients with asthma is generally good and unchanged during the last decade. Overweight, obesity, exacerbations, self-rated moderate/severe disease, heart disease, depression/anxiety and rhinitis were associated with lower HRQL, and high educational level and knowledge on self-management with higher HRQL. Highlights Questionnaire data on mini-AQLQ was obtained in two cohorts of patients with asthma. Mini-AQLQ scores did not change significantly between 2005 and 2015. Several risk factors were identified as risk factors for lower HRQL. High education and knowledge of self-management were associated with higher HRQL.


  • 주제어

    Asthma .   Health-related quality of life .   Mini-AQLQ .   Risk factors.  

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