본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences v.1072, 2018년, pp.305 - 314   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Multi-residue analysis of sedative drugs in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry

Zhang, Liqun (Center for Disease Control and Prevention of Hangzhou, Hangzhou 310021, PR China ) ; Wu, Pinggu (Center for Disease Control and Prevention of Zhejiang Province, Hangzhou 310009, PR China ) ; Jin, Quan (Center for Disease Control and Prevention of Hangzhou, Hangzhou 310021, PR China ) ; Hu, Zhengyan (Center for Disease Control and Prevention of Zhejiang Province, Hangzhou 310009, PR China ) ; Wang, Junlin (Center for Disease Control and Prevention of Zhejiang Province, Hangzhou 310009, PR China ) ;
  • 초록  

    Abstract Background Sedative drugs are often used for the treatment of depression, anxiety and insomnia and they are involved in many forensic cases. This work established a method for the simultaneous determination of multi-groups of sedative drugs (benzodiazepines, barbitals, phenothiazines, tricyclic antidepressant and butyrophenone) in human plasma for forensic analysis. A large number of sedative drugs with forensic interest can be analyzed in a short time with lower limits of quantification by combination of SPE extraction and ultra performance liquid chromatography-tandem mass spectrometry. Methods Sample preparation consisted of extraction of the plasma by hydrochloric acid solution and further purified by SLW solid phase extraction column. Results The method was fully validated to cover large concentration ranges of 50–1000μg/L for 5 Barbital drugs, while 1.0–50μg/L for the other 14 sedative drugs. The average recoveries of the drugs spiked at three levels ranged from 65.3% to 114.3% with the relative standard deviation between 1.2% and 13.2%. The lowest limits of quantification (LLOQ) were 100μg/L for Barbital drugs and1.0μg/L for all the other 14 drugs. Conclusions This validated method has been successfully used in emergency analysis of multi-residues of sedative drugs in plasma. Highlights Multi-group of tranquilizers in plasma were simultaneously detected by LC–MS/MS. The method was validated to be sensitive, precise and robust. It has been tested and validated for quick analysis of poisoning of tranquilizers.


  • 주제어

    Antipsychotic drugs .   Plasma .   Solid phase extraction .   LC–MS–MS.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기