본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Cancer letters v.414, 2018년, pp.16 - 25   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Roles of tRNA-derived fragments in human cancers

Sun, Chunxiao (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Fu, Ziyi (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Wang, Siwei (Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing 210009, China ) ; Li, Jun (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Li, Yongfei (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Zhang, Yanhong (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Yang, Fan (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Chu, Jiahui (Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China ) ; Wu, Hao (Department of Onc ) ; Huang, Xiang ; Li, Wei ; Yin, Yongmei ;
  • 초록  

    Abstract Transfer RNAs (tRNAs) were traditionally considered to participate in protein translation. Recent studies have identified a novel class of small non-coding RNAs (sncRNAs), produced by the specific cleavage of pre- and mature tRNAs, which have been named tRNA-derived fragments. tRNA-derived fragments are classified into diverse subtypes based on the different cleavage positions of the pre- and mature tRNAs. Recently, accumulated evidence has shown that these tRNA-derived fragments are frequently dysregulated in several cancers. Several tRNA-derived fragments were found to participate in cell proliferation, apoptosis, and invasive metastasis in several malignant human tumors. These dysregulated fragments are able to bind both Argonaute proteins and Piwi proteins to regulate gene expression. Some of the newly identified tRNA-derived fragments have been considered as the new biomarkers and therapeutic targets for the treatment of cancer. This review summarizes the biogenesis and biological functions of different subtypes of tRNA-derived fragments and discusses their molecular mechanisms in cancer progression. Highlights tRNA-derived fragments are frequently dysregulated in several cancers. Different types of tRNA-derived fragments have a variety of molecular functions. tRNA-derived fragments are new potential biomarkers and therapeutic targets in cancer. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    tRNA-derived fragments .   Cancer progression .   Gene regulation .   Biomarker.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기