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Cancer letters v.415, 2018년, pp.117 - 128   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The role of STAT3 in leading the crosstalk between human cancers and the immune system

Wang, Yu (Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ) ; Shen, Yicheng (University of Texas Medical Branch School of Medicine, Galveston, TX 77555, USA ) ; Wang, Sinan (Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Gastroenterology and Hepatology Institute, Tianjin 300070, China ) ; Shen, Qiang (Department of Clinical Cancer Prevention, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA ) ; Zhou, Xuan (Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China ) ;
  • 초록  

    Abstract The development and progression of human cancers are continuously and dynamically regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic pathways, signal transducer and activator of transcription 3 (STAT3) is constitutively activated both in tumor cells and tumor-infiltrated immune cells. Activated STAT3 persistently triggers tumor progression through direct regulation of oncogenic gene expression. Apart from its oncogenic role in regulating gene expression in tumor cells, STAT3 also paves the way for human cancer growth through immunosuppression. Activated STAT3 in immune cells results in inhibition of immune mediators and promotion of immunosuppressive factors. Therefore, STAT3 modulates the interaction between tumor cells and host immunity. Accumulating evidence suggests that targeting STAT3 may enhance anti-cancer immune responses and rescue the suppressed immunologic microenvironment in tumors. Taken together, STAT3 has emerged as a promising target in cancer immunotherapy. Highlights STAT3 is constitutively activated in both tumor cells and immune cells. Tumor progression can be triggered by STAT3 through direct regulation of oncogenes. STAT3 also mediates human cancer growth through tumor-induced immunosuppression. STAT3's dual role in both cancer and immunity renders it a promising target for cancer therapy.


  • 주제어

    STAT3 .   Immunity .   Immunosuppression .   Treg .   Cancer.  

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