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Cancer letters v.415, 2018년, pp.86 - 105   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

Ribeiro, Andreia    (Mountain Research Center (CIMO), ESA, Polytechnic Institute of Bragança, Bragança, Portugal   ); Abreu, Rui M.V.    (Mountain Research Center (CIMO), ESA, Polytechnic Institute of Bragança, Bragança, Portugal   ); Dias, Madalena M.    (Laboratory of Separation and Reaction Engineering –  ); Barreiro, Maria Filomena    (Laboratory of Catalysis and Materials (LSRE-LCM), Faculty of Engineering, University of Porto, Porto, Portugal   ); Ferreira, Isabel C.F.R.    (Laboratory of Separation and Reaction Engineering –  );
  • 초록  

    Abstract Angiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesis-related pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed. Highlights The current status of antiangiogenic drugs is presented. Natural extracts and molecules with antiangiogenic capacities are discussed. The angiogenesis molecular pathways and therapeutic targets are presented. Future challenges to increase the use of natural compounds are discussed.


  • 주제어

    Angiogenesis .   Molecular targets .   Synthetic drugs .   Natural compounds.  

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