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European journal of medicinal chemistry v.143, 2018년, pp.491 - 502   SCI SCIE
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Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors

Yuan, Haoliang (Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China ) ; Liu, Qiufeng (CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China ) ; Zhang, Li (Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China ) ; Hu, Shihe (Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China ) ; Chen, Tiantian (CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China ) ; Li, Huifang (Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, British Columbia V6H 3Z6, Canada ) ; Chen, Yadong (Laboratory of Molecular Design and Drug Discovery, School of Science, China Pharmaceutical Universit ) ; Xu, Yechun ; Lu, Tao ;
  • 초록  

    Abstract The c-Met kinase has emerged as an attractive target for developing antitumor agents because of its close relationship with the development of many human cancers, poor clinical outcomes and even drug resistance. A series of novel c-Met kinase inhibitors have been identified with multiple workflow in this work, including virtual screening, X-ray crystallography, biological evaluation and structural optimization. The experimentally determined crystal structure of the best hit compound HL-11 in c-Met kinase domain was highly consistent with the computational prediction. Comparison of the hit compounds with different c-Met kinase inhibitory activity by molecular dynamics simulations suggested the key protein-ligand interactions for structural optimization. Based on these, structural optimization produced compound 11e with better c-Met kinase inhibitory activity and improved anti-proliferative activity. These experimental findings proved the reliability and efficiency of our in silico methods. This strategy will facilitate further lead discovery and optimization for novel c-Met kinase inhibitors. Highlights Compound HL-11 identified with the reliable virtual screening workflow exhibited potent c-Met kinase inhibitory activity. Molecular dynamics simulations suggested the key protein-ligand interactions for structural optimization of compound HL-11 . The experimentally resolved crystal binding mode of compound HL-11 was highly consistent with the computational prediction. The novel compound 11e exhibited better c-Met kinase inhibitory activity and improved anti-proliferative activity. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    c-Met .   Virtual screening .   Pharmacophore .   X-ray crystallography .   Structural optimization.  

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