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International journal of cardiology v.250, 2018년, pp.66 - 72   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Female-specific survival advantage from transcatheter aortic valve implantation over surgical aortic valve replacement: Meta-analysis of the gender subgroups of randomised controlled trials including 3758 patients

Panoulas, Vasileios F. (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Francis, Darrel P. (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Ruparelia, Neil (Cardiology Department, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK ) ; Malik, Iqbal S. (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Chukwuemeka, Andrew (Cardiothoracic Department, Hammersmith Hospital, Imperial College Healthcare NHS Trust ) ; Sen, Sayan (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Anderson, Jonathan (Cardiothoracic Department, Hammersmith Hospital, Imperial College Healthcare NHS Trust ) ; Nihoyannopoulos, Petros (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Sutaria, Nilesh (Cardiovascular Sciences, National Heart and Lung Institute, Imperial College London, London, UK ) ; Hannan, Edward L. (School of Public Health, University at Albany, State University of New York, Albany, NY, USA ) ; Samadashvili, Zaza (School of Public Health, University at Alb ) ; D'Errigo, Paola ; Schymik, Gerhard ; Mehran, Roxana ; Chieffo, Alaide ; Latib, Azeem ; Presbitero, Patrizia ; Mehilli, Julinda ; Petronio, Anna Sonia ; Morice, Marie-Claude ; Tamburino, Corrado ; Thyregod, Hans G.H. ; Leon, Martin ; Colombo, Antonio ; Mikhail, Ghada W. ;
  • 초록  

    Abstract Transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) is the first area of interventional cardiology where women are treated as often as men. In this analysis of the gender specific results of randomised controlled trials (RCTs) comparing TAVI with surgical aortic valve replacement (SAVR) we aimed to determine whether gender affects the survival comparison between TAVI and SAVR. We identified all RCTs comparing TAVI versus SAVR for severe AS and reporting 1 and/or 2year survival. Summary odds ratios (ORs) were obtained using a random-effects model. Heterogeneity was assessed using the Q statistic and I 2 . Four RCTs met the criteria, totalling 3758 patients, 1706 women and 2052 men. Amongst females, TAVI recipients had a significantly lower mortality than SAVR recipients, at 1year (OR 0.68; 95%CI 0.50 to 0.94) and at 2years (OR 0.74; 95%CI 0.58 to 0.95). Amongst males there was no difference in mortality between TAVI and SAVR, at 1year (OR 1.09; 95%CI 0.86 to 1.39) or 2years (OR 1.05; 95%CI 0.85 to 1.3). The difference in treatment effect between genders was significant at both 1year (p interaction =0.02) and 0.02) and 2years (p interaction =0.04). In 0.04). In women TAVI has a 26 to 31% lower mortality odds than SAVR. In men, there is no difference in mortality between TAVI and SAVR.


  • 주제어

    Transcatheter aortic valve implantation .   Surgical aortic valve replacement .   Meta-analysis .   Female gender.  

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