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International journal of cardiology v.250, 2018년, pp.73 - 79   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Incidence and impact of renal dysfunction on clinical outcomes after transcatheter aortic valve implantation

Franzone, Anna (Department of Cardiology, University of Bern, Switzerland ) ; Stortecky, Stefan (Department of Cardiology, University of Bern, Switzerland ) ; Pilgrim, Thomas (Department of Cardiology, University of Bern, Switzerland ) ; Asami, Masahiko (Department of Cardiology, University of Bern, Switzerland ) ; Lanz, Jonas (Department of Cardiology, University of Bern, Switzerland ) ; Heg, Dik (Clinical Trials Unit Bern, University of Bern, Switzerland ) ; Langhammer, Bettina (Department of Cardiovascular Surgery, University of Bern, Switzerland ) ; Piccolo, Raffaele (Department of Cardiology, University of Bern, Switzerland ) ; Lee, Joe K.T. (Department of Cardiology, University of Bern, Switzerland ) ; Praz, Fabien (Department of Cardiology, University of Bern, Switzerland ) ; Räber, Lorenz (Department of Cardiology, University of Bern, Switzerland ) ; Valgimigli, Marco (Department of Cardiology, University of Bern, Switzerland ) ; Roost, Eva (Department of Cardiovascular Surgery, University of Bern, Switzerland ) ; Windecker, Stephan (Department of Cardiology, University of Bern, Switzerland ) ;
  • 초록  

    Abstract Background The impact of baseline renal dysfunction on early and late clinical outcomes after transcatheter aortic valve implantation (TAVI) remains to be defined. Methods 927 patients included in the prospective Bern TAVI registry were classified on the basis of the baseline estimated glomerular filtration rate (eGFR), as having none or mild (eGFR ≥60mL/min/1.73m 2 , n=284, 30.6%), moderate (eGFR between 30 and 59mL/min/1.73m 2 , n=535, 57.7%) and severe (eGFR 2 , n=108, 11.7%) renal dysfunction. Results A graded relationship between stages of renal dysfunction and increasing risk profile was observed with higher STS score and lower left ventricular ejection fraction among patients with eGFR adj, 3.90, 95% Confidence Interval, CI 1.15–13.2) and stage 3 acute kidney injury (HR adj 5.15, 95% CI 1.72–15.5) at 30-day follow-up, however no significant association was found for clinical outcomes at 1-year follow-up. Moreover, moderate and severe renal dysfunction were found to be associated with bleeding at 1-year follow-up (HR adj, 1.36, 95% CI 1.04–1.78 and HR adj 1.49, 95% CI 1.00–2.21, respectively). Conclusions Pre-procedural renal dysfunction differentially affects early clinical outcomes, although the magnitude of this association is diluted over time by the overriding effect of underlying risk and comorbidities.


  • 주제어

    Renal dysfunction .   Transcatheter aortic valve implantation .   Clinical outcomes.  

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