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Proceedings of the National Academy of Sciences of the United States of America v.115 no.6, 2018년, pp.1364 - 1369   SCI SCIE
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Transient visual pathway critical for normal development of primate grasping behavior

Mundinano, Inaki-Carril (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia ) ; Fox, Dylan M. (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia ) ; Kwan, William C. (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia ) ; Vidaurre, Diego (Oxford Centre for Human Brain Activity, Department of Psychiatry, University of Oxford, Oxford OX3 7JX, United Kingdom ) ; Teo, Leon (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia ) ; Homman-Ludiye, Jihane (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia ) ; Goodale, Melvyn A. (The Brain and Mind Institute, The University of Western Ontario, London, ON, Canada N6A 5B7 ) ; Leopold, David A. (Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892 ) ; Bourne, James A. (Australian Regenerative Medicine Institute, Monash University, Clayton, VIC 3800, Australia; ) ;
  • 초록  

    Significance Visually guided actions have been central to the neural and behavioral evolution of primates, culminating in precision grasping and object manipulation. Here, we reveal that the establishment and maturation of the cortical areas controlling reach-and-grasp behaviors are dependent on a transient visual pathway from the retina to the medial inferior pulvinar of the thalamus, which relays the information to the dorsal stream of the visual cortex, via the middle temporal (MT) area, in early life. Disruption of this pathway in early life leads to permanent anatomical, connectional, and reach-and-grasp behavior deficits. An evolutionary hallmark of anthropoid primates, including humans, is the use of vision to guide precise manual movements. These behaviors are reliant on a specialized visual input to the posterior parietal cortex. Here, we show that normal primate reaching-and-grasping behavior depends critically on a visual pathway through the thalamic pulvinar, which is thought to relay information to the middle temporal (MT) area during early life and then swiftly withdraws. Small MRI-guided lesions to a subdivision of the inferior pulvinar subnucleus (PIm) in the infant marmoset monkey led to permanent deficits in reaching-and-grasping behavior in the adult. This functional loss coincided with the abnormal anatomical development of multiple cortical areas responsible for the guidance of actions. Our study reveals that the transient retino–pulvinar–MT pathway underpins the development of visually guided manual behaviors in primates that are crucial for interacting with complex features in the environment.


  • 주제어

    prehension .   pulvinar .   marmoset .   thalamus .   visual cortex.  

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