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Science v.359 no.6376 = no.6376, 2018년, pp.658 - 662   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Live imaging of neurogenesis in the adult mouse hippocampus

Pilz, Gregor-Alexander (Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. ) ; Bottes, Sara (Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. ) ; Betizeau, Marion (Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. ) ; Jorg, David J. (Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK. ) ; Carta, Stefano (Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. ) ; Simons, Benjamin D. (Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, UK. ) ; Helmchen, Fritjof (Laboratory of Neural Circuit Dynamics, Faculties of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. ) ; Jessberger, Sebastian (Laboratory of Neural Plasticity, Faculties of Medicine and Science, Brain Research I ) ;
  • 초록  

    A window on hippocampal neurogenesis Addition of new neurons to the adult brain is key to the hippocampal functions of learning and memory. Pilz et al. labeled individual progenitor cells in the mouse hippocampus and watched them in situ for the next 2 months (see the Perspective by Gotz). The results revealed the developmental progression as progenitor cells gave rise to mature cells of the dentate gyrus. Science , this issue p. 658; see also p. 639 Neural stem and progenitor cells (NSPCs) generate neurons throughout life in the mammalian hippocampus. We used chronic in vivo imaging and followed genetically labeled individual NSPCs and their progeny in the mouse hippocampus for up to 2 months. We show that NSPCs targeted by the endogenous Achaete-scute homolog 1 (Ascl1) promoter undergo limited rounds of symmetric and asymmetric divisions, eliciting a burst of neurogenic activity, after which they are lost. Further, our data reveal unexpected asymmetric divisions of nonradial glia-like NSPCs. Cell fates of Ascl1-labeled lineages suggest a developmental-like program involving a sequential transition from a proliferative to a neurogenic phase. By providing a comprehensive description of lineage relationships, from dividing NSPCs to newborn neurons integrating into the hippocampal circuitry, our data offer insight into how NSPCs support life-long hippocampal neurogenesis.


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