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Journal of perinatal medicine v.46 no.2, 2018년, pp.209 - 217   SCI SCIE
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DHA reduces oxidative stress following hypoxia-ischemia in newborn piglets: a study of lipid peroxidation products in urine and plasma

Huun, Marianne Ullestad (Department of Pediatric Research , Institute of Surgical Research , Oslo University Hospital , Rikshospitalet, Oslo , Norway ) ; Garberg, Håvard T. (Department of Pediatric Research , Institute of Surgical Research , Oslo University Hospital , Rikshospitalet, Oslo , Norway ) ; Escobar, Javier (Neonatal Research Unit, Health Research Institute Hospital La Fé ) ; Chafer, Consuelo (, Valencia , Spain ) ; Vento, Maximo (Neonatal Research Unit, Health Research Institute Hospital La Fé ) ; Holme, Ingar M. (, Valencia , Spain ) ; Saugstad, Ola Didrik (Department of Sports Medicine , Norwegian School of Sports Sciences , Oslo , Norway ) ; Solberg, Rønnaug (Department of Pediatric Research , Institute of Surgical Research , Oslo University Hospital , Rikshospitalet, Oslo , Norway ) ;
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    Abstract Background:Lipid peroxidation mediated by reactive oxygen species is a major contributor to oxidative stress. Docosahexaenoic acid (DHA) has anti-oxidant and neuroprotective properties. Our objective was to assess how oxidative stress measured by lipid peroxidation was modified by DHA in a newborn piglet model of hypoxia-ischemia (HI).Methods:Fifty-five piglets were randomized to (i) hypoxia, (ii) DHA, (iii) hypothermia, (iv) hypothermia+DHA or (v) sham. All groups but sham were subjected to hypoxia by breathing 8% O2. DHA was administered 210 min after end of hypoxia and the piglets were euthanized 9.5 h after end of hypoxia. Urine and blood were harvested at these two time points and analyzed for F4-neuroprostanes, F2-isoprostanes, neurofuranes and isofuranes using UPLC-MS/MS.Results:F4-neuroprostanes in urine were significantly reduced (P=0.006) in groups receiving DHA. Hypoxia (median, IQR 1652 nM, 610–4557) vs. DHA (440 nM, 367–738, P=0.016) and hypothermia (median, IQR 1338 nM, 744–3085) vs. hypothermia+DHA (356 nM, 264–1180, P=0.006). The isoprostane compound 8-iso-PGF2α was significantly lower (P=0.011) in the DHA group compared to the hypoxia group. No significant differences were found between the groups in blood.Conclusion:DHA significantly reduces oxidative stress by measures of lipid peroxidation following HI in both normothermic and hypothermic piglets.


  • 주제어

    Docosahexaenoic acid (DHA) .   hypoxia-ischemia (HI) .   isoprostanes .   lipid peroxidation .   neuroprostanes .   neuroprotection .   oxidative stress .   reactive oxygen species.  

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